CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006950
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lanosterol synthase 
Protein Synonyms/Alias
 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC 
Gene Name
 ERG7 
Gene Synonyms/Alias
 YHR072W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
13SDTIGLPKTDPRLWRubiquitination[1]
628FLVSKQMKDGGWGESubiquitination[2]
670LFAEYPNKEVIDRGIubiquitination[1]
Reference
 [1] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. 
Sequence Annotation
 REPEAT 125 167 PFTB 1.
 REPEAT 566 603 PFTB 2.
 REPEAT 615 661 PFTB 3.
 ACT_SITE 234 234 Proton acceptor (By similarity).
 ACT_SITE 456 456 Proton donor (By similarity).
 MOD_RES 2 2 N-acetylthreonine.  
Keyword
 Acetylation; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Isomerase; Lipid biosynthesis; Lipid droplet; Lipid metabolism; Membrane; Reference proteome; Repeat; Steroid biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 731 AA 
Protein Sequence
MTEFYSDTIG LPKTDPRLWR LRTDELGRES WEYLTPQQAA NDPPSTFTQW LLQDPKFPQP 60
HPERNKHSPD FSAFDACHNG ASFFKLLQEP DSGIFPCQYK GPMFMTIGYV AVNYIAGIEI 120
PEHERIELIR YIVNTAHPVD GGWGLHSVDK STVFGTVLNY VILRLLGLPK DHPVCAKARS 180
TLLRLGGAIG SPHWGKIWLS ALNLYKWEGV NPAPPETWLL PYSLPMHPGR WWVHTRGVYI 240
PVSYLSLVKF SCPMTPLLEE LRNEIYTKPF DKINFSKNRN TVCGVDLYYP HSTTLNIANS 300
LVVFYEKYLR NRFIYSLSKK KVYDLIKTEL QNTDSLCIAP VNQAFCALVT LIEEGVDSEA 360
FQRLQYRFKD ALFHGPQGMT IMGTNGVQTW DCAFAIQYFF VAGLAERPEF YNTIVSAYKF 420
LCHAQFDTEC VPGSYRDKRK GAWGFSTKTQ GYTVADCTAE AIKAIIMVKN SPVFSEVHHM 480
ISSERLFEGI DVLLNLQNIG SFEYGSFATY EKIKAPLAME TLNPAEVFGN IMVEYPYVEC 540
TDSSVLGLTY FHKYFDYRKE EIRTRIRIAI EFIKKSQLPD GSWYGSWGIC FTYAGMFALE 600
ALHTVGETYE NSSTVRKGCD FLVSKQMKDG GWGESMKSSE LHSYVDSEKS LVVQTAWALI 660
ALLFAEYPNK EVIDRGIDLL KNRQEESGEW KFESVEGVFN HSCAIEYPSY RFLFPIKALG 720
MYSRAYETHT L 731 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005811; C:lipid particle; IDA:SGD.
 GO:0000250; F:lanosterol synthase activity; IMP:SGD.
 GO:0006696; P:ergosterol biosynthetic process; IMP:SGD. 
Interpro
 IPR001330; Prenyltrans.
 IPR018333; Squalene_cyclase.
 IPR002365; Terpene_synthase_CS.
 IPR008930; Terpenoid_cyclase/PrenylTrfase. 
Pfam
 PF00432; Prenyltrans 
SMART
  
PROSITE
 PS01074; TERPENE_SYNTHASES 
PRINTS