UniProt Accession

 MBIP1_MOUSE; Q99LQ1; Q3TBM3 

Genbank Protein ID

 AK077125; AK154318; AK171164; BC002277 

Genbank Nucleotide ID

 BAC36628.1; BAE32511.1; BAE42286.1; AAH02277.1 

Protein Name

 MAP3K12-binding inhibitory protein 1 

Protein Synonyms/Alias

 MAPK upstream kinase-binding inhibitory protein; MUK-binding inhibitory protein 

Gene Name

 Mbip 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
299	QSVNFSGKRRKVQPP	acetylation	[1, 2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). 

Sequence Annotation

 REGION 170 341 Interaction with MAP3K12.
 REGION 269 283 Leucine-zipper 1 (Potential).
 REGION 312 327 Leucine-zipper 2 (Potential).
 MOD_RES 91 91 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 341 AA 

Protein Sequence

Gene Ontology

 GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IDA:MGI.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0043966; P:histone H3 acetylation; IEA:Compara. 

Interpro

 IPR026062; MBIP. 

Pfam

  

SMART

  

PROSITE

  

PRINTS