UniProt Accession

 RIBA_ECOLI; P0A7I7; P25523; P78147 

Genbank Protein ID

 X67876; U00096; AP009048; X60293 

Genbank Nucleotide ID

 CAA48075.1; AAC74359.1; BAA14831.1; CAA42835.1 

Protein Name

 GTP cyclohydrolase-2 

Protein Synonyms/Alias

 GTP cyclohydrolase II 

Gene Name

 ribA 

Gene Synonyms/Alias

 b1277; JW1269 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
101	RNIGLLNKIRAYALQ	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. 

Sequence Annotation

 NP_BIND 49 53 GTP.
 NP_BIND 92 94 GTP.
 ACT_SITE 126 126 Proton acceptor (Potential).
 ACT_SITE 128 128 Nucleophile.
 METAL 54 54 Zinc; catalytic.
 METAL 65 65 Zinc; catalytic.
 METAL 67 67 Zinc; catalytic.
 BINDING 70 70 GTP.
 BINDING 114 114 GTP.
 BINDING 149 149 GTP.
 BINDING 154 154 GTP.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; GTP-binding; Hydrolase; Metal-binding; Nucleotide-binding; Reference proteome; Riboflavin biosynthesis; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 196 AA 

Protein Sequence

Gene Ontology

 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003935; F:GTP cyclohydrolase II activity; IDA:EcoCyc.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:0009231; P:riboflavin biosynthetic process; IEA:HAMAP. 

Interpro

 IPR000926; GTP_CycHdrlaseII_RibA. 

Pfam

 PF00925; GTP_cyclohydro2 

SMART

  

PROSITE

  

PRINTS