| Tag | Content |
|---|
| CPLM ID | CPLM-019529 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Guanylate-binding protein 4 |
Protein Synonyms/Alias | GTP-binding protein 4; GBP-4; Guanine nucleotide-binding protein 4 |
Gene Name | GBP4 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 404 | KLVDTIEKKKGDFVL | acetylation | [1] |
|
Reference | [1] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y. Mol Cell. 2006 Aug;23(4):607-18. [ PMID: 16916647] |
Functional Description | Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity). |
Sequence Annotation | NP_BIND 60 67 GTP (By similarity).
NP_BIND 82 84 GTP (By similarity).
NP_BIND 112 116 GTP (By similarity).
REGION 1 325 GTPase domain (Globular) (By similarity). |
Keyword | Coiled coil; Complete proteome; Cytoplasm; GTP-binding; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 640 AA |
Protein Sequence | MGERTLHAAV PTPGYPESES IMMAPICLVE NQEEQLTVNS KALEILDKIS QPVVVVAIVG 60
LYRTGKSYLM NRLAGKRNGF PLGSTVQSET KGIWMWCVPH LSKPNHTLVL LDTEGLGDVE 120
KSNPKNDSWI FALAVLLSSS FVYNSVSTIN HQALEQLHYV TELAELIRAK SCPRPDEAED 180
SSEFASFFPD FIWTVRDFTL ELKLDGNPIT EDEYLENALK LIPGKNPKIQ NSNMPRECIR 240
HFFRKRKCFV FDRPTNDKQY LNHMDEVPEE NLERHFLMQS DNFCSYIFTH AKTKTLREGI 300
IVTGKRLGTL VVTYVDAINS GAVPCLENAV TALAQLENPA AVQRAADHYS QQMAQQLRLP 360
TDTLQELLDV HAACEREAIA VFMEHSFKDE NHEFQKKLVD TIEKKKGDFV LQNEEASAKY 420
CQAELKRLSE HLTESILRGI FSVPGGHNLY LEEKKQVEWD YKLVPRKGVK ANEVLQNFLQ 480
SQVVVEESIL QSDKALTAGE KAIAAERAMK EAAEKEQELL REKQKEQQQM MEAQERSFQE 540
YMAQMEKKLE EERENLLREH ERLLKHKLKV QEEMLKEEFQ KKSEQLNKEI NQLKEKIEST 600
KNEQLRLLKI LDMASNIMIV TLPGASKLLG VGTKYLGSRI 640 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |