UniProt Accession

 SRA1_HUMAN; Q9HD15; Q6NVU9; Q8IXM1; Q9HD13; Q9HD14 

Genbank Protein ID

 AF293024; AF293025; AF293026; AF318361; AF092038; BC040043 

Genbank Nucleotide ID

 AAG02114.1; AAG02115.1; AAG02116.1; AAL55868.1; AAH40043.2 

Protein Name

 Steroid receptor RNA activator 1 

Protein Synonyms/Alias

 Steroid receptor RNA activator protein; SRAP 

Gene Name

 SRA1 

Gene Synonyms/Alias

 PP7684 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
83	GPPPPSSKAPRSPPV	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis. 

Sequence Annotation

 MOD_RES 60 60 Phosphoserine.  

Keyword

 Activator; Apoptosis; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Ribonucleoprotein; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 236 AA 

Protein Sequence

Gene Ontology

 GO:0031252; C:cell leading edge; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0030529; C:ribonucleoprotein complex; IPI:UniProtKB.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IEA:Compara.
 GO:0010861; F:thyroid hormone receptor activator activity; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IDA:UniProtKB.
 GO:0030154; P:cell differentiation; IDA:UniProtKB.
 GO:0008283; P:cell proliferation; IDA:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR009917; SRA1-protein/COPII_Sec31. 

Pfam

 PF07304; SRA1 

SMART

  

PROSITE

  

PRINTS