CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033763
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide 
Protein Synonyms/Alias
  
Gene Name
 YWHAZ 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
3*****MDKNELVQKAubiquitination[1]
9DKNELVQKAKLAEQAubiquitination[1]
11NELVQKAKLAEQAERubiquitination[1]
49NLLSVAYKNVVGARRubiquitination[1]
74QKTEGAEKKQQMAREubiquitination[1]
75KTEGAEKKQQMAREYubiquitination[1]
115NASQAESKVFYLKMKubiquitination[1]
120ESKVFYLKMKGDYYRubiquitination[1]
122KVFYLKMKGDYYRYLubiquitination[1]
139VAAGDDKKGIVDQSQubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Monooxygenase; Oxidoreductase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 245 AA 
Protein Sequence
MDKNELVQKA KLAEQAERYD DMAACMKSVT EQGAELSNEE RNLLSVAYKN VVGARRSSWR 60
VVSSIEQKTE GAEKKQQMAR EYREKIETEL RDICNDVLSL LEKFLIPNAS QAESKVFYLK 120
MKGDYYRYLA EVAAGDDKKG IVDQSQQAYQ EAFEISKKEM QPTHPIRLGL ALNFSVFYYE 180
ILNSPEKACS LAKTAFDEAI AELDTLSEES YKDSTLIMQL LRDNLTLWTS DTQGDEAEAG 240
EGGEN 245 
Gene Ontology
 GO:0031252; C:cell leading edge; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
 GO:0002553; P:histamine secretion by mast cell; IEA:Compara.
 GO:0006626; P:protein targeting to mitochondrion; IEA:Compara.
 GO:0010941; P:regulation of cell death; IEA:Compara. 
Interpro
 IPR000308; 14-3-3.
 IPR023409; 14-3-3_CS.
 IPR023410; 14-3-3_domain. 
Pfam
 PF00244; 14-3-3 
SMART
 SM00101; 14_3_3 
PROSITE
 PS00796; 1433_1
 PS00797; 1433_2 
PRINTS
 PR00305; 1433ZETA.