UniProt Accession

 IST1_MOUSE; Q9CX00; Q80U68 

Genbank Protein ID

 AK010262; AK088192; AK152830; BC017605; AK122215 

Genbank Nucleotide ID

 BAB26804.1; BAC40200.1; BAE31530.1; AAH17605.1; BAC65497.1 

Protein Name

 IST1 homolog 

Protein Synonyms/Alias

  

Gene Name

 Ist1 

Gene Synonyms/Alias

 Kiaa0174 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
127	VADQLCAKYSKEYGK	acetylation	[1]
127	VADQLCAKYSKEYGK	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (By similarity). 

Sequence Annotation

  

Keyword

 Cell cycle; Cell division; Complete proteome; Cytoplasmic vesicle; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 362 AA 

Protein Sequence

Gene Ontology

 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0048672; P:positive regulation of collateral sprouting; IGI:MGI. 

Interpro

 IPR005061; DUF292_euk. 

Pfam

 PF03398; Ist1 

SMART

  

PROSITE

  

PRINTS