UniProt Accession

 T22D3_MOUSE; Q9Z2S7; B1AVF3; Q3UNI6; Q8K160; Q9EQN0; Q9EQN1; Q9EQN2 

Genbank Protein ID

 AF024519; AF201287; AF201288; AF201289; AK083389; AK144196; AL683809; BC028813 

Genbank Nucleotide ID

 AAD01789.1; AAG41220.1; AAG41221.1; AAG41222.1; BAC38897.1; BAE25761.1; CAM24436.1; AAH28813.1 

Protein Name

 TSC22 domain family protein 3 

Protein Synonyms/Alias

 Glucocorticoid-induced leucine zipper protein; TSC22-related-inducible leucine zipper 3; Tilz3 

Gene Name

 Tsc22d3 

Gene Synonyms/Alias

 Dsip1; Dsipi; Gilz 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
52	NFRQLQEKLVFENLN	ubiquitination	[1]
62	FENLNTDKLNNIMRQ	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). 

Sequence Annotation

 REGION 1 60 AP1-binding.
 REGION 76 97 Leucine-zipper.  

Keyword

 Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 137 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0007589; P:body fluid secretion; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:0048642; P:negative regulation of skeletal muscle tissue development; IDA:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0006970; P:response to osmotic stress; IDA:MGI. 

Interpro

 IPR000580; TSC-22_Dip_Bun. 

Pfam

 PF01166; TSC22 

SMART

  

PROSITE

 PS01289; TSC22 

PRINTS