CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022022
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cell death regulator Aven 
Protein Synonyms/Alias
  
Gene Name
 AVEN 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
215PLEVPQVKPKRTDDGubiquitination[1, 2, 3, 4]
217EVPQVKPKRTDDGKGubiquitination[3, 4]
230KGLGMQLKGPLGPGGubiquitination[5]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
 Protects against apoptosis mediated by Apaf-1. 
Sequence Annotation
 MOD_RES 94 94 Phosphoserine.  
Keyword
 Apoptosis; Complete proteome; Membrane; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 362 AA 
Protein Sequence
MQAERGARGG RGRRPGRGRP GGDRHSERPG AAAAVARGGG GGGGGDGGGR RGRGRGRGFR 60
GARGGRGGGG APRGSRREPG GWGAGASAPV EDDSDAETYG EENDEQGNYS KRKIVSNWDR 120
YQDIEKEVNN ESGESQRGTD FSVLLSSAGD SFSQFRFAEE KEWDSEASCP KQNSAFYVDS 180
ELLVRALQEL PLCLRLNVAA ELVQGTVPLE VPQVKPKRTD DGKGLGMQLK GPLGPGGRGP 240
IFELKSVAAG CPVLLGKDNP SPGPSRDSQK PTSPLQSAGD HLEEELDLLL NLDAPIKEGD 300
NILPDQTSQD LKSKEDGEVV QEEEVCAKPS VTEEKNMEPE QPSTSKNVTE EELEDWLDSM 360
IS 362 
Gene Ontology
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0005622; C:intracellular; IDA:UniProtKB.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB. 
Interpro
 IPR026187; Aven. 
Pfam
  
SMART
  
PROSITE
  
PRINTS