CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039124
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Adenylate cyclase type 2 
Protein Synonyms/Alias
  
Gene Name
 Adcy2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
600FLWKNKFKKEREEIEubiquitination[1]
601LWKNKFKKEREEIETubiquitination[1]
833VKGKGDLKTYFVNTEacetylation[2]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lyase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 852 AA 
Protein Sequence
QERLLLSLLP AHIAMEMKAE IIQRLQGPKA GQMENTNNFH NLYVKRHTNV SILYADIVGF 60
TRLASDCSPG ELVHMLNELF GKFDQIAKEN ECMRIKILGD CYYCVSGLPI SLPNHAKNCV 120
KMGLDMCEAI KKVRDATGVD INMRVGVHSG NVLCGVIGLQ KWQYDVWSHD VTLANHMEAG 180
GVPGRVHISS VTLEHLNGAY KVEEGDGEIR DPYLKQHLVK TYFVINPKGE RRSPQHLFRP 240
RHTLDGAKMR ASVRMTRYLE SWGAAKPFAH LHHRDSMTTE NGKISTTDVP MGQHNFQNRT 300
LRTKSQKKRF EEELNERMIQ AIDGINAQKQ WLKSEDIQRI SLLFYNKNIE KEYRATALPA 360
FKYYVTCACL IFLCIFIVQI LVLPKTSILG FSFGAAFLSL IFILFVCFAG QLLQCSKKAS 420
TSLMWLLKSS GIIANRPWPR ISLTIVTTAI ILTMAVFNMF FLSNSEETTL PTANTSNANV 480
SVPDNQASIL HARNLFFLPY FIYSCILGLI SCSVFLRVNY ELKMLIMMVA LVGYNTILLH 540
THAHVLDAYS QVLFQRPGIW KDLKTMGSVS LSIFFITLLV LGRQSEYYCR LDFLWKNKFK 600
KEREEIETME NLNRVLLENV LPAHVAEHFL ARSLKNEELY HQSYDCVCVM FASIPDFKEF 660
YTESDVNKEG LECLRLLNEI IADFDDLLSK PKFSGVEKIK TIGSTYMAAT GLSAIPSQEH 720
AQEPERQYMH IGTMVEFAYA LVGKLDAINK HSFNDFKLRV GINHGPVIAG VIGAQKPQYD 780
IWGNTVNVAS RMDSTGVLDK IQVTEETSLI LQTLGYTCTC RGIINVKGKG DLKTYFVNTE 840
MSRSLSQSNL AS 852 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0004016; F:adenylate cyclase activity; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0006171; P:cAMP biosynthetic process; IEA:GOC.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 
Interpro
 IPR001054; A/G_cyclase.
 IPR018297; A/G_cyclase_CS.
 IPR009398; Adenylate_cyclase-like. 
Pfam
 PF06327; DUF1053
 PF00211; Guanylate_cyc 
SMART
 SM00044; CYCc 
PROSITE
 PS00452; GUANYLATE_CYCLASE_1
 PS50125; GUANYLATE_CYCLASE_2 
PRINTS