UniProt Accession

 ALBU_RAT; P02770; P11382; Q5U3X3 

Genbank Protein ID

 V01222; BC085359 

Genbank Nucleotide ID

 CAA24532.1; AAH85359.1 

Protein Name

 Serum albumin 

Protein Synonyms/Alias

  

Gene Name

 Alb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
28	VFRREAHKSEIAHRF	acetylation	[1]
36	SEIAHRFKDLGEQHF	acetylation	[1]
57	AFSQYLQKCPYEEHI	acetylation	[1]
65	CPYEEHIKLVQEVTD	acetylation	[1]
97	IHTLFGDKLCAIPKL	acetylation	[1]
103	DKLCAIPKLRDNYGE	acetylation	[1]
205	KAACLTPKLDAVKEK	acetylation	[1]
210	TPKLDAVKEKALVAA	acetylation	[1]
212	KLDAVKEKALVAAVR	acetylation	[1]
223	AAVRQRMKCSSMQRF	acetylation	[1]
236	RFGERAFKAWAVARM	acetylation	[1]
257	AEFAEITKLATDVTK	acetylation	[1]
264	KLATDVTKINKECCH	acetylation	[1]
305	KLQACCDKPVLQKSQ	acetylation	[1]
341	VEDKEVCKNYAEAKD	acetylation	[1]
375	SLLLRLAKKYEATLE	acetylation	[1]
376	LLLRLAKKYEATLEK	acetylation	[1]
413	EEPKNLVKTNCELYE	acetylation	[1]
421	TNCELYEKLGEYGFQ	acetylation	[1]
438	VLVRYTQKAPQVSTP	acetylation	[1]
490	RLCVLHEKTPVSEKV	acetylation	[1]
496	EKTPVSEKVTKCCSG	acetylation	[1]
543	DICTLPDKEKQIKKQ	acetylation	[1]
558	TALAELVKHKPKATE	acetylation	[1]
569	KATEDQLKTVMGDFA	acetylation	[1]
588	KCCKAADKDNCFATE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. 

Sequence Annotation

 DOMAIN 19 211 Albumin 1.
 DOMAIN 212 403 Albumin 2.
 DOMAIN 404 601 Albumin 3.
 METAL 27 27 Copper.
 METAL 91 91 Zinc (By similarity).
 METAL 123 123 Zinc (By similarity).
 METAL 271 271 Zinc (By similarity).
 METAL 273 273 Zinc (By similarity).
 MOD_RES 443 443 Phosphoserine (By similarity).
 MOD_RES 444 444 Phosphothreonine (By similarity).
 MOD_RES 446 446 Phosphothreonine (By similarity).
 DISULFID 77 86 By similarity.
 DISULFID 99 115 By similarity.
 DISULFID 114 125 By similarity.
 DISULFID 148 193 By similarity.
 DISULFID 192 201 By similarity.
 DISULFID 224 270 By similarity.
 DISULFID 269 277 By similarity.
 DISULFID 289 303 By similarity.
 DISULFID 302 313 By similarity.
 DISULFID 340 385 By similarity.
 DISULFID 384 393 By similarity.
 DISULFID 416 462 By similarity.
 DISULFID 461 472 By similarity.
 DISULFID 485 501 By similarity.
 DISULFID 500 511 By similarity.
 DISULFID 538 583 By similarity.
 DISULFID 582 591 By similarity.  

Keyword

 Cleavage on pair of basic residues; Complete proteome; Copper; Direct protein sequencing; Disulfide bond; Lipid-binding; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 608 AA 

Protein Sequence

Gene Ontology

 GO:0005604; C:basement membrane; IDA:RGD.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005615; C:extracellular space; IDA:RGD.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0043234; C:protein complex; ISS:UniProtKB.
 GO:0003677; F:DNA binding; ISS:UniProtKB.
 GO:0008144; F:drug binding; ISS:UniProtKB.
 GO:0005504; F:fatty acid binding; ISS:UniProtKB.
 GO:0019825; F:oxygen binding; IEA:Compara.
 GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
 GO:0015643; F:toxic substance binding; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IDA:RGD.
 GO:0009267; P:cellular response to starvation; ISS:UniProtKB.
 GO:0019836; P:hemolysis by symbiont of host erythrocytes; ISS:UniProtKB.
 GO:0051659; P:maintenance of mitochondrion location; ISS:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
 GO:0046010; P:positive regulation of circadian sleep/wake cycle, non-REM sleep; IDA:RGD.
 GO:0046689; P:response to mercury ion; IEP:RGD.
 GO:0007584; P:response to nutrient; IEP:RGD.
 GO:0010033; P:response to organic substance; IEP:RGD.
 GO:0070541; P:response to platinum ion; IEP:RGD.
 GO:0006810; P:transport; IEA:InterPro.
 GO:0042311; P:vasodilation; NAS:RGD. 

Interpro

 IPR000264; ALB/AFP/VDB.
 IPR020858; Serum_albumin-like.
 IPR021177; Serum_albumin/AFP.
 IPR020857; Serum_albumin_CS.
 IPR014760; Serum_albumin_N. 

Pfam

 PF00273; Serum_albumin 

SMART

 SM00103; ALBUMIN 

PROSITE

 PS00212; ALBUMIN_1
 PS51438; ALBUMIN_2 

PRINTS

 PR00802; SERUMALBUMIN.