CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017523
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ankyrin repeat domain-containing protein 42 
Protein Synonyms/Alias
  
Gene Name
 ANKRD42 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
40AVRAGDVKQLSEIVCubiquitination[1]
129VDPSVTDKREWRPVHubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
 REPEAT 25 60 ANK 1.
 REPEAT 64 93 ANK 2.
 REPEAT 97 126 ANK 3.
 REPEAT 130 159 ANK 4.
 REPEAT 163 192 ANK 5.
 REPEAT 200 232 ANK 6.
 REPEAT 235 265 ANK 7.
 REPEAT 269 298 ANK 8.
 REPEAT 302 332 ANK 9.  
Keyword
 Alternative splicing; ANK repeat; Complete proteome; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 389 AA 
Protein Sequence
MPGVANSGPS TSSRETANPC SRKKVHFGSI HDAVRAGDVK QLSEIVCLHW LLWHGADITH 60
VTTRGWTASH IAAIRGQDAC VQALIMNGAN LTAQDDRGCT PLHLAATHGH SFTLQIMLRS 120
GVDPSVTDKR EWRPVHYAAF HGRLGCLQLL VKWGCSIEDV DYNGNLPVHL AAMEGHLHCF 180
KFLVSRMSSA TQVLKAFNDN GENVLDLAQR FFKQNILQFI QGAEYEGKDL EDQETLAFPG 240
HVAAFKGDLG MLKKLVEDGV ININERADNG STPMHKAAGQ GHIECLQWLI KMGADSNITN 300
KAGERPSDVA KRFAHLAAVK LLEELQKYDI DDENEIDEND VKYFIRHGVE GSTDAKDDLC 360
LSDLDKTDAR RPSKNCRASW SMNDYVEKN 389 
Gene Ontology
 GO:0005634; C:nucleus; IEA:Compara.
 GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IEA:Compara.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Compara. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR018247; EF_Hand_1_Ca_BS. 
Pfam
 PF12796; Ank_2 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS
 PR01415; ANKYRIN.