UniProt Accession

 RDH12_HUMAN; Q96NR8; B2RDA2; Q8TAW6 

Genbank Protein ID

 AK054835; AK315462; AL049779; CH471061; BC025724 

Genbank Nucleotide ID

 BAB70811.1; BAG37849.1; EAW80951.1; AAH25724.1 

Protein Name

 Retinol dehydrogenase 12 

Protein Synonyms/Alias

 All-trans and 9-cis retinol dehydrogenase 

Gene Name

 RDH12 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
103	KLDLSDTKSIRAFAE	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments. 

Sequence Annotation

 NP_BIND 46 52 NADP (By similarity).
 ACT_SITE 200 200 Proton acceptor (By similarity).
 BINDING 175 175 Substrate (By similarity).  

Keyword

 Complete proteome; Disease mutation; Leber congenital amaurosis; NADP; Oxidoreductase; Polymorphism; Reference proteome; Retinitis pigmentosa; Sensory transduction; Vision. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 316 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IDA:UniProtKB.
 GO:0060342; C:photoreceptor inner segment membrane; TAS:Reactome.
 GO:0004745; F:retinol dehydrogenase activity; IDA:UniProtKB.
 GO:0045494; P:photoreceptor cell maintenance; TAS:UniProtKB.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0042572; P:retinol metabolic process; IDA:UniProtKB. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.