CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031885
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 TPR and ankyrin repeat-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 TRANK1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
336QNTCAMEKSGRIYTEubiquitination[1]
488IGRSGTGKTTCCLYRubiquitination[1]
677RNEDGSLKRTIIGWSubiquitination[2]
1308TKTLPISKLSYSASQubiquitination[1, 2]
1696SENPMACKEILKPNYmethylation[3]
2019QVPERLLKVVKRVLVubiquitination[1]
2022ERLLKVVKRVLVAVNubiquitination[4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2375 AA 
Protein Sequence
MHILFQKGML KRVKKLLDLL VKFDINFNLK NKEGKDARHR IKKNDSLLLA WNKALMENRR 60
RSRQDSAAHL GKLSKSTAPG HTSQLKSQGS FKSVPCGATA RTLPEGSAVP DSWETLPGTQ 120
VTRKEPGALR PCSLRDCLMQ DITVLIQQVE VDPSFPEDCL QSSEPLEAGA GKEGKKDDKP 180
TLGAGAPDCS EVGEGHAQVG LGALQLVPDD NRGKEGNDDQ DDWSTQEIEA CLQDFDNMTW 240
EIECTSEMLK KLSSKVMTKV IKKKIILAIQ QLGNGEWTQG LQKRLKHLKG SIQLFEAKLD 300
KGARMLWELA IDFSPRCSEN PEKIIATEQN TCAMEKSGRI YTEIIRIWDI VLDHCKLADS 360
IKAICNAYNR GLSCVLRKKL KGINKGQVSA NMKIQKRIPR CYVEDTEAEK GREHVNPEYF 420
PPASAVETEY NIMKFHSFST NMAFNILNDT TATVEYPFRV GELEYAVIDL NPRPLEPIIL 480
IGRSGTGKTT CCLYRLWKKF HVYWEKAEQA GSPLLAKQVW LKRRLEVEPG KESPGGEEEE 540
EEEDEEEEDS IEVETVESID EQEYEACAGG AGVEPAGDGQ AAEVCAPEHP HQLEHLHQIF 600
VTKNHVLCQE VQRNFIELSK STKATSHYKP LDPNIHKLQD LRDENFPLFV TSKQLLLLLD 660
ASLPKPFFLR NEDGSLKRTI IGWSAQEEST IPSWQEDEEE AEVDGDYSEE DKAVEMRTGD 720
SDPRVYVTFE VFKNEIWPKM TKGRTAYNPA LIWKEIKSFL KGSFEALSCP HGRLTEEVYK 780
KLGRKRCPNF KEDRSEIYSL FSLYQQIRSQ KGYFDEEDVL YNISRRLSKL RVLPWSIHEL 840
YGDEIQDFTQ AELALLMKCI NDPNSMFLTG DTAQSIMKGV AFRFSDLRSL FHYASRNTID 900
KQCAVRKPKK IHQLYQNYRS HSGILNLASG VVDLLQFYFP ESFDRLPRDS GLFDGPKPTV 960
LESCSVSDLA ILLRGNKRKT QPIEFGAHQV ILVANETAKE KIPEELGLAL VLTIYEAKGL 1020
EFDDVLLYNF FTDSEAYKEW KIISSFTPTS TDSREENRPL VEVPLDKPGS SQGRSLMVNP 1080
EMYKLLNGEL KQLYTAITRA RVNLWIFDEN REKRAPAFKY FIRRDFVQVV KTDENKDFDD 1140
SMFVKTSTPA EWIAQGDYYA KHQCWKVAAK CYQKGGAFEK EKLALAHDTA LSMKSKKVSP 1200
KEKQLEYLEL AKTYLECKEP TLSLKCLSYA KEFQLSAQLC ERLGKIRDAA YFYKRSQCYK 1260
DAFRCFEQIQ EFDLALKMYC QEELFEEAAI AVEKYEEMLK TKTLPISKLS YSASQFYLEA 1320
AAKYLSANKM KEMMAVLSKL DIEDQLVFLK SRKRLAEAAD LLNREGRREE AALLMKQHGC 1380
LLEAARLTAD KDFQASCLLG AARLNVARDS DIEHTKDILR EALDICYQTG QLSGIAEAHF 1440
LQGVILRDFQ KLRDAFFKFD TLNHSAGVVE ALYEAASQCE AEPEKILGLA PGGLEILLSL 1500
VRALKRVTNN AEKEMVKSCF EFFGISQVDA KYCQIAQNDP GPILRIIFDL DLNLREKKTK 1560
DHFLIMTDQV KLALNKHLLG RLCQITRSLL GKTYRGVCMR FIVGLKCEDE NCEHFHRPLR 1620
RCEAKCLVQS KMNLVAINGL LLEAKKVFPK ILAEELKEID YILSTDMYGL CKSILDVLFP 1680
KHFHQRVLSE NPMACKEILK PNYKSFRFYR FALKEYIHFL FENESARNRR ESTDLWLSAM 1740
QAFLLSSNYP EEFEKLLHQE EDNYNRELKA LESEKDERGR GRGSRIKGIE GKFGMLAPNR 1800
DDENMDKTHL CFIRLLENCI DQFYVYRNPE DYKRLFFRFM NVLIKRCKEP LIPSIGNTVA 1860
LLEFQFIHCG VVLARLWKNV ILCLPKSYIA LLHYWEFLFS KKDKELGDVF SIIQEYKPKD 1920
VTRAIQDFRF HLSYLAKVLC GYENVNFNVL LDAFSEIDYV VSGEAERTLV LCLVMLVNAE 1980
EILQPYCKPL LYRHFREIES RLQLMSMDCP GQVPERLLKV VKRVLVAVNV KSVAEALQDL 2040
LFERDEEYLM DCDWRWDPVH TKGSIVRGLY YEEVRLNRLL CLDPVDYFAE PECEFGQDEM 2100
DELALEDRDH VLATILSQKQ RKASIQRKLR RACLVVSLCI SWRRRVGTQM ERVREEAREP 2160
RAGNFKKADV DRTQCDLCGV KFTRGPENYF SPSKAFEGAA SEVAVLSRAE LEREECQERN 2220
SESYEQHIHL EHHQRQQVAY QKYSEFFHEK VDPAIDEGKL VVQDIEQSVW IHSHVGSKEH 2280
SHMLQKVQEH IKRVSDMVED LYRRKAWAGA EEAMTRLVNI LILSVRDARD WLMKTETRLK 2340
KEGIVQEDDY ENEVEDFGEL RPRRRSRKCG KQRKY 2375 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro. 
Interpro
 IPR014017; DNA_helicase_UvrD-like_C.
 IPR000212; DNA_helicase_UvrD/REP.
 IPR027417; P-loop_NTPase.
 IPR014016; UvrD-like_ATP-bd. 
Pfam
 PF00580; UvrD-helicase
 PF13361; UvrD_C 
SMART
  
PROSITE
  
PRINTS