| Tag | Content |
|---|
| CPLM ID | CPLM-003853 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tubulin alpha chain |
Protein Synonyms/Alias | Alpha-tubulin |
Gene Name | |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Toxoplasma gondii |
NCBI Taxa ID | 5811 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 40 | DGQMPSDKTIGGGDD | acetylation | [1] |
|
Reference | [1] Post-translational modifications to Toxoplasma gondii alpha- and beta-tubulins include novel C-terminal methylation. Xiao H, El Bissati K, Verdier-Pinard P, Burd B, Zhang H, Kim K, Fiser A, Angeletti RH, Weiss LM. J Proteome Res. 2010 Jan;9(1):359-72. [ PMID: 19886702] |
Functional Description | Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. |
Sequence Annotation | NP_BIND 142 148 GTP (Potential).
MOD_RES 40 40 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Cytoplasm; Cytoskeleton; GTP-binding; Microtubule; Nucleotide-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 453 AA |
Protein Sequence | MREVISIHVG QAGIQIGNAC WELFCLEHGI QPDGQMPSDK TIGGGDDAFN TFFSETGAGK 60
HVPRCVFLDL EPTVVDEVRT GTYRHLFHPE QLISGKEDAA NNFARGHYTI GKEIVDLSLD 120
RIRKLADNCT GLQGFLMFNA VGGGTGSGLG CLLLERLSVD YGKKSKLNFC SWPSPQVSTA 180
VVEPYNSVLS THSLLEHTDV AVMLDNEAIY DICRRNLDIE RPTYTNLNRL IAQVISSLTA 240
SLRFDGALNV DVTEFQTNLV PYPRIHFMLS SYAPIISAEK AYHEQLSVAE ITNSAFEPAS 300
MMAKCDPRHG KYMACCLMYR GDVVPKDVNA AVATIKTKRT IQFVDWCPTG FKCGINYQPP 360
TVVPGGDLAK VMRAVCMISN STAIAEVFSR MDHKFDLMYA KRAFVHWYVG EGMEEGEFSE 420
AREDLAALEK DYEEVGIETA EGEGEEEGYG DEY 453 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0003924; F:GTPase activity; IEA:InterPro. GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro. GO:0007017; P:microtubule-based process; IEA:InterPro. GO:0051258; P:protein polymerization; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |