CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017705
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bardet-Biedl syndrome 1 protein 
Protein Synonyms/Alias
 BBS2-like protein 2 
Gene Name
 BBS1 
Gene Synonyms/Alias
 BBS2L2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
190RIDPLTLKEMLESIRubiquitination[1]
245TTMTTLKKNLADEDAubiquitination[1]
356HGFTHKGKKLWTVQMubiquitination[1]
398EVRIYRDKALLNVIHubiquitination[1]
602KGISDIIKVLVLREGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.  
Keyword
 Acetylation; Alternative splicing; Bardet-Biedl syndrome; Cell membrane; Cell projection; Ciliopathy; Cilium; Complete proteome; Cytoplasm; Disease mutation; Membrane; Mental retardation; Obesity; Polymorphism; Reference proteome; Sensory transduction; Vision. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 593 AA 
Protein Sequence
MDPSWRRSSH SWPQPMPDSG RAPVRPHLAK LEEDVWPCPQ FHQTKAASGP PFVNEANSKW 60
LDAHYDPMAN IHTFSACLAL ADLHGDGEYK LVVGDLGPGG QQPRLKVLKG PLVMTESPLP 120
ALPAAAATFL MEQHEPRTPA LALASGPCVY VYKNLRPYFK FSLPQLPPNP LEQDLWNQAK 180
EDRIDPLTLK EMLESIRETA EEPLSIQSLR FLQLELSEME AFVNQHKSNS IKRQTVITTM 240
TTLKKNLADE DAVSCLVLGT ENKELLVLDP EAFTILAKMS LPSVPVFLEV SGQFDVEFRL 300
AAACRNGNIY ILRRDSKHPK YCIELSAQPV GLIRVHKVLV VGSTQDSLHG FTHKGKKLWT 360
VQMPAAILTM NLLEQHSRGL QAVMAGLANG EVRIYRDKAL LNVIHTPDAV TSLCFGRYGR 420
EDNTLIMTTR GGGLIIKILK RTAVFVEGGS EVGPPPAQAM KLNVPRKTRL YVDQTLRERE 480
AGTAMHRAFQ TDLYLLRLRA ARAYLQALES SLSPLSTTAR EPLKLHAVVQ GLGPTFKLTL 540
HLQNTSTTRP VLGLLVCFLY NEALYSLPRA FFKVPLLVPG LNYPLETFVE SLSNKGISDI 600
IKVLVLREGQ SAPLLSAHVN MPGSEGLAAA 630 
Gene Ontology
 GO:0034464; C:BBSome; IDA:BHF-UCL.
 GO:0060170; C:cilium membrane; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0043001; P:Golgi to plasma membrane protein transport; IMP:MGI.
 GO:0035058; P:nonmotile primary cilium assembly; IMP:BHF-UCL.
 GO:0045494; P:photoreceptor cell maintenance; IMP:BHF-UCL.
 GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
 GO:0001895; P:retina homeostasis; IMP:BHF-UCL. 
Interpro
 IPR011047; Quinonprotein_ADH-like_supfam. 
Pfam
  
SMART
  
PROSITE
  
PRINTS