CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023850
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Absent in melanoma 1 protein 
Protein Synonyms/Alias
 Beta/gamma crystallin domain-containing protein 1 
Gene Name
 AIM1 
Gene Synonyms/Alias
 CRYBG1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
755VFTFGLGKKKESQPEubiquitination[1]
988TDFMGLFKSSRYDPSubiquitination[2]
1016LRGSVQNKLNPRPGKubiquitination[2]
1332SEKNFGSKGSSIDVLubiquitination[2]
1346LGIVANLKETGYGVKubiquitination[2]
1396DWGGKNCKISSVQPIubiquitination[2]
1516REDFKGKKIELNAETubiquitination[2]
1611NGNLEDLKLLRIQVMubiquitination[2]
1709IILNTVSKEKFTQVWubiquitination[2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. 
Sequence Annotation
 DOMAIN 1022 1061 Beta/gamma crystallin 'Greek key' 1.
 DOMAIN 1062 1117 Beta/gamma crystallin 'Greek key' 2.
 DOMAIN 1123 1163 Beta/gamma crystallin 'Greek key' 3.
 DOMAIN 1164 1206 Beta/gamma crystallin 'Greek key' 4.
 DOMAIN 1218 1270 Beta/gamma crystallin 'Greek key' 5.
 DOMAIN 1271 1313 Beta/gamma crystallin 'Greek key' 6.
 DOMAIN 1319 1361 Beta/gamma crystallin 'Greek key' 7.
 DOMAIN 1362 1404 Beta/gamma crystallin 'Greek key' 8.
 DOMAIN 1415 1452 Beta/gamma crystallin 'Greek key' 9.
 DOMAIN 1453 1496 Beta/gamma crystallin 'Greek key' 10.
 DOMAIN 1502 1542 Beta/gamma crystallin 'Greek key' 11.
 DOMAIN 1543 1584 Beta/gamma crystallin 'Greek key' 12.
 DOMAIN 1586 1719 Ricin B-type lectin.
 MOD_RES 75 75 Phosphoserine.
 MOD_RES 329 329 Phosphoserine.
 MOD_RES 525 525 Phosphothreonine.  
Keyword
 3D-structure; Complete proteome; Lectin; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1723 AA 
Protein Sequence
MEKRSSGRRS GRRRGSQKST DSPGADAELP ESAARDDAVF DDEVAPNAAS DNASAEKKVK 60
SPRAALDGGV ASAASPESKP SPGTKGQLRG ESDRSKQPPP ASSPTKRKGR SRALEAVPAP 120
PASGPRAPAK ESPPKRVPDP SPVTKGTAAE SGEEAARAIP RELPVKSSSL LPEIKPEHKR 180
GPLPNHFNGR AEGGRSRELG RAAGAPGASD ADGLKPRNHF GVGRSTVTTK VTLPAKPKHV 240
ELNLKTPKNL DSLGNEHNPF SQPVHKGNTA TKISLFENKR TNSSPRHTDI RGQRNTPASS 300
KTFVGRAKLN LAKKAKEMEQ PEKKVMPNSP QNGVLVKETA IETKVTVSEE EILPATRGMN 360
GDSSENQALG PQPNQDDKAD VQTDAGCLSE PVASALIPVK DHKLLEKEDS EAADSKSLVL 420
ENVTDTAQDI PTTVDTKDLP PTAMPKPQHT FSDSQSPAES SPGPSLSLSA PAPGDVPKDT 480
CVQSPISSFP CTDLKVSENH KGCVLPVSRQ NNEKMPLLEL GGETTPPLST ERSPEAVGSE 540
CPSRVLVQVR SFVLPVESTQ DVSSQVIPES SEVREVQLPT CHSNEPEVVS VASCAPPQEE 600
VLGNEHSHCT AELAAKSGPQ VIPPASEKTL PIQAQSQGSR TPLMAESSPT NSPSSGNHLA 660
TPQRPDQTVT NGQDSPASLL NISAGSDDSV FDSSSDMEKF TEIIKQMDSA VCMPMKRKKA 720
RMPNSPAPHF AMPPIHEDHL EKVFDPKVFT FGLGKKKESQ PEMSPALHLM QNLDTKSKLR 780
PKRASAEQSV LFKSLHTNTN GNSEPLVMPE INDKENRDVT NGGIKRSRLE KSALFSSLLS 840
SLPQDKIFSP SVTSVNTMTT AFSTSQNGSL SQSSVSQPTT EGAPPCGLNK EQSNLLPDNS 900
LKVFNFNSSS TSHSSLKSPS HMEKYPQKEK TKEDLDSRSN LHLPETKFSE LSKLKNDDME 960
KANHIESVIK SNLPNCANSD TDFMGLFKSS RYDPSISFSG MSLSDTMTLR GSVQNKLNPR 1020
PGKVVIYSEP DVSEKCIEVF SDIQDCSSWS LSPVILIKVV RGCWILYEQP NFEGHSIPLE 1080
EGELELSGLW GIEDILERHE EAESDKPVVI GSIRHVVQDY RVSHIDLFTE PEGLGILSSY 1140
FDDTEEMQGF GVMQKTCSMK VHWGTWLIYE EPGFQGVPFI LEPGEYPDLS FWDTEEAYIG 1200
SMRPLKMGGR KVEFPTDPKV VVYEKPFFEG KCVELETGMC SFVMEGGETE EATGDDHLPF 1260
TSVGSMKVLR GIWVAYEKPG FTGHQYLLEE GEYRDWKAWG GYNGELQSLR PILGDFSNAH 1320
MIMYSEKNFG SKGSSIDVLG IVANLKETGY GVKTQSINVL SGVWVAYENP DFTGEQYILD 1380
KGFYTSFEDW GGKNCKISSV QPICLDSFTG PRRRNQIHLF SEPQFQGHSQ SFEETTSQID 1440
DSFSTKSCRV SGGSWVVYDG ENFTGNQYVL EEGHYPCLSA MGCPPGATFK SLRFIDVEFS 1500
EPTIILFERE DFKGKKIELN AETVNLRSLG FNTQIRSVQV IGGIWVTYEY GSYRGRQFLL 1560
SPAEVPNWYE FSGCRQIGSL RPFVQKRIYF RLRNKATGLF MSTNGNLEDL KLLRIQVMED 1620
VGADDQIWIY QEGCIKCRIA EDCCLTIVGS LVTSGSKLGL ALDQNADSQF WSLKSDGRIY 1680
SKLKPNLVLD IKGGTQYDQN HIILNTVSKE KFTQVWEAMV LYT 1723 
Gene Ontology
  
Interpro
 IPR001064; Beta/gamma_crystallin.
 IPR011024; G_crystallin-rel.
 IPR000772; Ricin_B_lectin. 
Pfam
 PF00030; Crystall
 PF00652; Ricin_B_lectin 
SMART
 SM00458; RICIN
 SM00247; XTALbg 
PROSITE
 PS50915; CRYSTALLIN_BETA_GAMMA
 PS50231; RICIN_B_LECTIN 
PRINTS
 PR01367; BGCRYSTALLIN.