CPLM-018589

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-018589

UniProt Accession

RN185_MOUSE; Q91YT2; Q6ZWS3

Genbank Protein ID

AK034108; AK052436; AK053358; AK075756; AK077638; AK149640; AK165895; AK167455; AK168904; BC014812

Genbank Nucleotide ID

BAC28589.1; BAC34989.1; BAC35361.1; BAC35934.1; BAC36918.1; BAE29001.1; BAE38444.1; BAE39541.1; BAE40718.1; AAH14812.1

Protein Name

E3 ubiquitin-protein ligase RNF185

Protein Synonyms/Alias

RING finger protein 185

Gene Name

Rnf185

Gene Synonyms/Alias

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
116	RQVCPVCKAGISRDK	ubiquitination	[1]
123	KAGISRDKVIPLYGR	ubiquitination	[1]
141	GQQDPREKTPPRPQG	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Mitochondrial E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (By similarity).

Sequence Annotation

ZN_FING 39 80 RING-type.

Keyword

Alternative splicing; Autophagy; Complete proteome; Ligase; Membrane; Metal-binding; Mitochondrion; Mitochondrion outer membrane; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation pathway; Zinc; Zinc-finger.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

192 AA

Protein Sequence

MCILLCPHMF CRPINQRQAD WDCLENLPWK LCWQAAMASK GPSASASTEN SNAGGPSGSS 60
NGTGESGGQD STFECNICLD TAKDAVISLC GHLFCWPCLH QWLETRPNRQ VCPVCKAGIS 120
RDKVIPLYGR GSTGQQDPRE KTPPRPQGQR PEPENRGGFQ GFGFGDGGFQ MSFGIGAFPF 180
GIFATAFNIN DGRPPPAVPG TPQYVDEQFL SRLFLFVALV IMFWLLIA 228

Gene Ontology

GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006914; P:autophagy; IEA:UniProtKB-KW.
GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.

Interpro

IPR001841; Znf_RING.
IPR013083; Znf_RING/FYVE/PHD.
IPR017907; Znf_RING_CS.

Pfam

SMART

SM00184; RING

PROSITE

PS00518; ZF_RING_1
PS50089; ZF_RING_2

PRINTS