UniProt Accession

 PROF1_RAT; P62963; P10924 

Genbank Protein ID

 X96967; BC062405 

Genbank Nucleotide ID

 CAA65655.1; AAH62405.1 

Protein Name

 Profilin-1 

Protein Synonyms/Alias

 Profilin I 

Gene Name

 Pfn1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
54	EVGVLVGKDRSSFFV	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 108 108 N6-acetyllysine (By similarity).
 MOD_RES 129 129 Phosphotyrosine (By similarity).
 MOD_RES 138 138 Phosphoserine; by ROCK1 (By similarity).
 CROSSLNK 54 54 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Isopeptide bond; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 140 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0045202; C:synapse; IDA:RGD.
 GO:0003779; F:actin binding; TAS:RGD.
 GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:RGD.
 GO:0005102; F:receptor binding; IDA:RGD.
 GO:0008154; P:actin polymerization or depolymerization; TAS:RGD.
 GO:0071363; P:cellular response to growth factor stimulus; IEP:RGD.
 GO:0001843; P:neural tube closure; IEA:Compara.
 GO:0051054; P:positive regulation of DNA metabolic process; IDA:RGD.
 GO:0051496; P:positive regulation of stress fiber assembly; IMP:RGD.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:RGD.
 GO:0050434; P:positive regulation of viral transcription; IMP:RGD. 

Interpro

 IPR005454; Profilin_chordates.
 IPR027310; Profilin_CS.
 IPR005455; Profilin_eukaryotes/bac. 

Pfam

 PF00235; Profilin 

SMART

 SM00392; PROF 

PROSITE

 PS00414; PROFILIN 

PRINTS

 PR01639; PROFILINMAML.