CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004361
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Long-chain specific acyl-CoA dehydrogenase, mitochondrial 
Protein Synonyms/Alias
 LCAD 
Gene Name
 Acadl 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
42RLETPSAKKLTDIGIacetylation[1]
43LETPSAKKLTDIGIRacetylation[1]
66IFRESVRKFFQEEVIacetylation[1]
81PYHEEWEKAGEVSREacetylation[1]
92VSRELWEKAGKQGLLacetylation[1]
95ELWEKAGKQGLLGINacetylation[1]
165IPQMTAGKCIGAIAMacetylation[1]
240FLVENGMKGFIKGKKacetylation[1]
254KLHKMGMKAQDTAELacetylation[1]
279ALLGEENKGFYYLMQacetylation[1]
318RNYVRQRKAFGKTVAacetylation[1]
322RQRKAFGKTVAHIQTacetylation[1]
333HIQTVQHKLAELKTNacetylation[1]
358CLQLHETKRLDSASAacetylation[1]
419GGTNEIMKELIARQIacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Direct protein sequencing; FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Mitochondrion; Oxidoreductase; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 430 AA 
Protein Sequence
MAARLLLRSL RVLSARSATL PPPSARCSHS GAEARLETPS AKKLTDIGIR RIFSSEHDIF 60
RESVRKFFQE EVIPYHEEWE KAGEVSRELW EKAGKQGLLG INIAEKHGGI GGDLLSTAVT 120
WEEQAYSNCT GPGFSLHSDI VMPYIANYGT KEQIEQFIPQ MTAGKCIGAI AMTEPGAGSD 180
LQGVRTNAKR SGSDWILNGS KVFITNGWLS DLVIVVAVTN REARSPAHGI SLFLVENGMK 240
GFIKGKKLHK MGMKAQDTAE LFFEDVRLPA SALLGEENKG FYYLMQELPQ ERLLIADLAI 300
SACEFMFEET RNYVRQRKAF GKTVAHIQTV QHKLAELKTN ICVTRAFVDS CLQLHETKRL 360
DSASASMAKY WASELQNTVA YQCVQLHGGW GYMWEYPIAK AYVDARVQPI YGGTNEIMKE 420
LIARQIVSDS 430 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IDA:BHF-UCL.
 GO:0031966; C:mitochondrial membrane; IDA:BHF-UCL.
 GO:0000062; F:fatty-acyl-CoA binding; IDA:RGD.
 GO:0050660; F:flavin adenine dinucleotide binding; IDA:RGD.
 GO:0004466; F:long-chain-acyl-CoA dehydrogenase activity; IDA:RGD.
 GO:0016401; F:palmitoyl-CoA oxidase activity; IEA:Compara.
 GO:0042413; P:carnitine catabolic process; IEA:Compara.
 GO:0019254; P:carnitine metabolic process, CoA-linked; IEA:Compara.
 GO:0033539; P:fatty acid beta-oxidation using acyl-CoA dehydrogenase; IDA:RGD.
 GO:0042758; P:long-chain fatty acid catabolic process; IDA:RGD.
 GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:Compara.
 GO:0046322; P:negative regulation of fatty acid oxidation; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IDA:RGD.
 GO:0090181; P:regulation of cholesterol metabolic process; IEA:Compara.
 GO:0001659; P:temperature homeostasis; IEA:Compara. 
Interpro
 IPR006089; Acyl-CoA_DH_CS.
 IPR006092; Acyl-CoA_DH_N.
 IPR006090; Acyl-CoA_Oxase/DH_1.
 IPR006091; Acyl-CoA_Oxase/DH_cen-dom.
 IPR009075; AcylCo_DH/oxidase_C.
 IPR013786; AcylCoA_DH/ox_N.
 IPR009100; AcylCoA_DH/oxidase. 
Pfam
 PF00441; Acyl-CoA_dh_1
 PF02770; Acyl-CoA_dh_M
 PF02771; Acyl-CoA_dh_N 
SMART
  
PROSITE
 PS00072; ACYL_COA_DH_1
 PS00073; ACYL_COA_DH_2 
PRINTS