Tag | Content |
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CPLM ID | CPLM-028037 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | BIR-containing ubiquitin-conjugating enzyme |
Protein Synonyms/Alias | Bruce |
Gene Name | Bruce |
Gene Synonyms/Alias | CG6303; Dmel_CG6303 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
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4520 | VVSHHFEKMVRLAGD | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | |
Sequence Annotation | |
Keyword | Complete proteome; Ligase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 4876 AA |
Protein Sequence | MATEQHHQQR VLKQDGYLDL GDCNSAPSRP FEMRNVVYHP QLNVLLLFDN GSTVKVLDAN 60 SGVILQTYHL SSNGDSIVHG RYMPLQDKIL FWDGHNLGLR GDYNGVLLLD TILQAPIGQN 120 DDYIKLEIIL SEAIIFQNCI TELESEGLEC PCDISNELTQ KINQAQLKAK KGIKAQRWNT 180 ICLEVPYSSL KLVSNNMVIL LKRLERHIPV LAIASAINER LTDMMMGSRV PDFGWNFSNF 240 QRVLMHSEAV RRQTFEKWPH MDYKWALPDQ MAQAGFYHQP SSSGEDRAMC FTCSVCLVCW 300 EKTDEPWSEH ERHSPLCPFV KGEYTQNVPL SITYATNPAL PAPGLGFDII SNSDYANVLC 360 TSCSQTGELS VWSIERHLKL MHTFHVPTLL NYIFEESFEW ARVTAICVLP NARARTKVNY 420 VYSAANYGGS GSSNGAGCNS GLNAVSGGKF GSVNAQHITS TSTLRAGVVG SKIVLGVSVR 480 QSSGELALRM VVLNIVEVDR NSESSTSVSN DSGSVSSGGG QLMKSSSPMV NVSAENNATV 540 TQVNLESKDD DNKAMTPYEK FADGFDSNGF VSALMTYNKN NGVSQNTDDA SALYDFDLCT 600 LSQILDHNLE EPLSLMVGSS NTVNVSNIGM GNEINKLVVD VEISHQNNNN NNNNNNEASS 660 LGGNSSNNNN NIMINGGTNS SIDKMTAIEE IDCVVESWTS VKRMNALDGA SSGVNGVNHM 720 DQEVIEIAEI LPTTPKCNQL LVKLLRTKAP EAEGSKIIMA TVAKEEEEED EEQRTDESME 780 TDNNAEGNVA AQLLVFDYDD TEISNDYTLA MTFSRAKFPK QLCILPHFNS SPEHKDAGSI 840 CVVCADGTVE IYSLADFQGT MVIEEEGEHF ESVVYCRNLD RLCCCSRQGG LLFYSLSDGE 900 NDSGDELLEM DDDCSTTLTQ AADVSVTDGG RQLARTDLLG KTLLANESIC MDAGSEAAAI 960 PNSSSAAQGA HVQTSPSASS APSTNANLLA YKTADLTLED LKVFYALTQF DDKLTVYSAE 1020 VPSCWNDIGQ VQNQRKQSQN MRHGGDERDF TRTWRLHNDA TTWDEHIIEL NLAQPVSLGH 1080 IDLKFTVYQQ CSNPAAIQVT LLKQNNNGFG YRMKGPHSSY KPNVIDDNID LSYIANENPV 1140 LSEEYLLAHN AEVLAGPIEL SSCIDLCDQG GTATLTSPKL FKTRTRNFLL HIKTVSDPSK 1200 DGQNKTRGCD WLHEISISVR AVKSHSRISN GRMQRIAMLE SNVLLVQLLR IASDPASSSL 1260 AKNLSLDILN WICFIRLNRF RSPKSERLKD QINKQTAANI QDLLAQQFEC ISLAEKHIEQ 1320 LLRNCVIYSE RSTAHKCVKL LIMLTEGATN LPAEVQDHTT LDYSFKAAIA NTFPELPRAQ 1380 CGSVVRWYMM LTCATSTAES HNSISEQAIS LLKEIAAEID KRWDPHCALL CTRFGLYGYP 1440 FEPEIFDFDF PNVSRQGPGS SVANVIRSSP TILPVTGLDI KRLSSIDGVD FRTFPYLIRG 1500 KSISNQLRGL LEVVQLHFNC VQTSEATRID NIDSVGGNTG ANVIIEDVMM MPKQVVAKEK 1560 GEEMLNDLVN DVECLVEEMK VDENEKQEKV DYDAFGLVNG FKDKTLSSLN SVKQTLKEEV 1620 KKEKADIMDK LTIAKFLPKL SLLESYMQKK INEHISFDDF GKLDNWDGNT TPPFNLEVEA 1680 PIVCSEATSE SNMSQQATSA GGNILDDAAD SEKITESLNA NPCQPIAWHK LITPPPKQMI 1740 VIDRMHSGAR RFVVLDFGQH ILLTDLVIPS CDELTSLNID IWCFDEETDC TRLVQVNDIQ 1800 TKTLVLSDIQ PAPICRYLKL TIIGRIGMSA TKCKVPLGRF FGHPVVLEHD GYGDQLMKYI 1860 KHPTHSLQSQ IKSLNALYED VHCRYSLASS KLMDLLAPMR NSELSNVAHL QAFINKQREE 1920 ELSGLENNNK VVSLYDECML LQYQINVIRN VVLRLERALS PNSPTTTLLP GQSIPLTEDI 1980 LRAASRDKLR VLSLSLVEVL LHFSIEYGIK NILPVHQRFN AATAKALFNA LVVYGDAQLQ 2040 LATCSLLVRM CCFQPWWGDF LADTFCSLFS AQNCKAFPQD RIFFLLTYLG RRSIAMGACR 2100 SIVIDAVLKT LVKLLAPISP HYKFQSEQPS TSANAADRNA AMGTTSDLQL ITWLLLFLSV 2160 CLDDNERKDK SAARWDFMSC EGDFTKARPS ATPNIKQLRC FKKRIIQQNK YLAQPYADWG 2220 KKIYMIQNEH PGIFMELSTK SKGAGPTKST STGGKINMGS SGLCVGGPSS SSGNTSKSAA 2280 SSSSPKNQAV PGTDGERDSN FDKGLKSLRM DNIKVVIRGL FALLLEMDFD CNMDQFLLTC 2340 KVIARLVAAC RPSVQLCKIV TIAQLQQLVR LSVWNDQQHP WAVHAITCLL QDLLDADKQF 2400 RDNDVTPTND TPRTMEAAIQ ETRDLFSDYT STASSCTEAL FETLMPTARE FYQEAVKYNY 2460 LPSLIECDDT EFDEMLNDID MIERTKPVTK KESNALSKNT FNFFCKSISI ALDSRLDVGL 2520 ELHVETQLRR LTNRTSLDLY SSLPQVLTNE FVSPPPEAAP WPEYLTQLWS GTEYNGDNTY 2580 VMFKRVFDSI LAELHLEDTW VHLEQVLQMW LTLNCELSDK PYTSGITHSD VPKIPFGANA 2640 VQGLLLALAW HSDIKLRTWC LGFQCLFLAC NSLPIGDDAD CTRINEAIVN DENFEKVLLR 2700 FFSGYGMSSS IITNRCAGPT ICKHLHELLL WLHSKSETSG IPCKRRLKDI LLHVVLQLVQ 2760 PGGSISNQQG PIDAQNQLVR DLLMMPNDKG DLNIALKITE SVSFLVYNNI SNGERLQCQR 2820 GNENSPVGNN FSNLFANVLG SENPNKQNAA ICDNSLIINL LKLSSHMVLT EMPRQPSEVT 2880 IPEEEELSNQ SQTDETKAEQ LNTEGHRSKV PCIADWVLRH FPTMKRLFGT LSQCSTNTFT 2940 MMSSGCFFSP KSNMILDDPQ TIADAVFSLM ITLNDKASHP RLVVVPICRY LEETTIPRNA 3000 TLPRLPHSEP FLWYISKVLE VPAAVQTFTQ LGGIQIICHS LVRLNKTIIN MQPGLISLIM 3060 QHLTRNTRFK RNNHVAASSA CKKTTTGTGT TCPTSAQPPR SAAQYDGLIN FAPFSHIVSE 3120 NDATQSAEVL ISNPNNSHRR PRSPAWTYMF YPNETHVDLT ITLPTAILLK EVQLVPHTTS 3180 LASCPSAVAL ELSRDYGLGS IPVGAPMATT GLTCIRLKLA KAEVATSIVL RLYKPKDCGN 3240 VGLVQIAVLG QTIFGNRMHG LRSPSPFIDS LATCSSPVQT AVLAAMDADS MLEDDAFAKT 3300 SIGWVRILSR CFHVAALQPD SKLADLIAAY PAAYPGFLEA CCSLLNIMPM IPSLAQQHLE 3360 TILLKLSAYN HEISLQLLRT LLWHTTPQVF KLSSDSVCDL IYEVVTGSTE HLLDKLRVLI 3420 DWVMQLHDNY SKQARCNNPQ SGFVKVIASI LWKVHTQQQL PELPLLISSS LFETCFEWVS 3480 SLEHDEPLKS SFDSLLCALC FIKPELFNQL LVKLGVKLEP PARGQTDDSK VQSGSAWFRR 3540 EGSENLSVLL QRPTFLKTLA LACQSPAAVY QMLDSGLPKL LAHAIYEYCM HLMPGSEPVA 3600 SASTVPEDEP LANNQAAAAA DDEDSSLTDF DKAEANVVYN TPLLSSSNVP KVLDFFAECC 3660 AEGPMRDWLG TMQGSVFWKP LLQLLCNTHA AQFSKTLPKE QSFIRLERAT INFFTRVSAC 3720 HPGNQENLTS LLIGAIICKP LRFSHGVRPT ISGFTRQMVL QLLLENEHIT VSVRSQQPLQ 3780 RRDTLSAVLG GISSGASTSL PVAAVNNHPA RRSSAHHMLF TVTTSTTCQE IMQNCVSVFS 3840 NLVYQQPTDQ RAGETSASSS GVSSATAKSS ESKMEKSSFL NFNNVEAGSM EFLTVGAAVA 3900 AKDKRIKDAK NQAAMNKDKE TQTSSTNLAS NIFNVDEFLL QSANAVNGNQ LVIPEYSDIV 3960 LAGDATISQV LASLQNAGHS LSTPCISFDL VLQQRSDDTS EAKKTKAACT EPLPSPLQRF 4020 SSSGGLSLLA HYLPTVYPEH SGRKTTLVFS EKEKSPPLSD WVKLEPNDEI YEDLEDTLCE 4080 PAAKLATVSS VPQHSLAAFG LFLRLPAYSD VLLRDKMRAQ CLLRLVLGVT GDGDGNDIYS 4140 LSLAPSLPTL PFEVFRQLLD SVPLSTDDGV LLRRVVIEVG AMHLVLNCLG IFSHQSHNNR 4200 IGAPISEPSP SGTSSGSGTI GNGSGNGSVS GTKTNAPEEA TPSATSDDKS HMYWAKGTGF 4260 GTGSTTQSWN VEQALLRQKS EEEHVTVLLL VLASYINPGD CIPSEMCGED ILAYHDVRDV 4320 TGELPPIFQT LLQQSCLIPA LSSYLRNDSV LDITRHIPLY RAILKLLRAL SLSKMLVSLL 4380 QPSASGSGDS TPPIVELLTS MKTCVDTYAK RLKVNKKSNI KGQTHQLTFN IDDGDDEGLA 4440 LLIPDIHETS VLVQKTTDAD ALINMLHTNE DGSAQLEPQS KSIEQRYLEL MKKRQFDTFD 4500 MIVESDNNSF RFVVSHHFEK MVRLAGDRYH PSRVKRLAQE AVTLSTSLPL SFSSSVFVRC 4560 DTDRLDIMKV LITGPADTPY ANGCFEFDVF FPPDYPNQPM LINLETTGRH SVRFNPNLYN 4620 DGKVCLSVLN TWHGRPEEKW NAQTSSFLQV LVSIQSLILV PEPYFNEPGF ERSRGSPSGT 4680 NSSREYNSNI YQACVRWAML EQIRSPSQCF KDVIHKHFWL KREEICAQIE GWIEELGKPQ 4740 YTERASRTIS FNSMVLRRHY RHLREELSKL KPPRGLEDLD APFNPVATLP PMDVSAVAPS 4800 LAATNTVQAQ PDDAIVTDIT LLGENADECE ADGDAEGDGE VDDGFKGFPQ EEGLLTGEEE 4860 VVEILSDTEN ESSMWQ 4876 |
Gene Ontology | GO:0004842; F:ubiquitin-protein ligase activity; ISS:FlyBase. GO:0043066; P:negative regulation of apoptotic process; IDA:FlyBase. GO:0012501; P:programmed cell death; IGI:FlyBase. GO:0007286; P:spermatid development; IMP:FlyBase. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |