| Tag | Content |
|---|
| CPLM ID | CPLM-021057 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cleavage and polyadenylation specificity factor subunit 1 |
Protein Synonyms/Alias | Cleavage and polyadenylation specificity factor 160 kDa subunit; CPSF 160 kDa subunit |
Gene Name | Cpsf1 |
Gene Synonyms/Alias | Cpsf160 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 399 | LLLKYTEKLQEPPAS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). |
Sequence Annotation | |
Keyword | Complete proteome; mRNA processing; Nucleus; Reference proteome; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1441 AA |
Protein Sequence | MYAVYKQAHP PTGLEFTMYC NFFNNSERNL VVAGTSQLYV YRLNRDAEAL TKNDGSTEGK 60
AHREKLELVA SFSFFGNVMS MASVQLAGAK RDALLLSFKD AKLSVVEYDP GTHDLKTLSL 120
HYFEEPELRD GFVQNVHTPR VRVDPDGRCA AMLIYGTRLV VLPFRRESLA EEHEGLMGEG 180
QRSSFLPSYI IDVRALDEKL LNIIDLQFLH GYYEPTLLIL FEPNQTWPGR VAVRQDTCSI 240
VAISLNITQK VHPVIWSLTS LPFDCTQALA VPKPIGGVVI FAVNSLLYLN QSVPPYGVAL 300
NSLTTGTTAF PLRTQEGVRI TLDCAQAAFI SYDKMVISLK GGEIYVLTLI TDGMRSVRAF 360
HFDKAAASVL TTSMVTMEPG YLFLGSRLGN SLLLKYTEKL QEPPASSVRE AADKEEPPSK 420
KKRVEPAVGW TGGKTVPQDE VDEIEVYGSE AQSGTQLATY SFEVCDSMLN IGPCANAAVG 480
EPAFLSEEFQ NSPEPDLEIV VCSGYGKNGA LSVLQKSIRP QVVTTFELPG CYDMWTVIAP 540
VRKEEEETPK AESTEQEPSA PKAEEDGRRH GFLILSREDS TMILQTGQEI MELDTSGFAT 600
QGPTVFAGNI GDNRYIVQVS PLGIRLLEGV NQLHFIPVDL GAPIVQCAVA DPYVVIMSAE 660
GHVTMFLLKS DSYGGRHHRL ALHKPPLHHQ SKVIALCLYR DVSGMFTTES RLGGARDELG 720
GRSGSEAEGL GSETSPTVDD EEEMLYGDSS ALFSPSKEEA RRSSQPPADR DPAPFKADPT 780
HWCLLVRENG TMEIYQLPDW RLVFLVKNFP VGQRVLVDSS FGQPTTQGEV RKEEATRQGE 840
LPLVKEVLLV ALGSRQSRPY LLVHVDQELL IYEAFPHDSQ LGQGNLKVRF KKVPHNINFR 900
EKKPKPSKKK AEGCSTEEGS GGRGRVARFR YFEDIYGYSG VFICGPSPHW LLVTGRGALR 960
LHPMGIDGPI DSFAPFHNVN CPRGFLYFNR QGELRISVLP AYLSYDAPWP VRKIPLRCTA 1020
HYVAYHVESK VYAVATSTNT PCTRIPRMTG EEKEFEAIER DDRYIHPQQE AFSIQLISPV 1080
SWEAIPNARI ELEEWEHVTC MKTVSLRSEE TVSGLKGYVA AGTCLMQGEE VTCRGRILIM 1140
DVIEVVPEPG QPLTKNKFKV LYEKEQKGPV TALCHCNGHL VSAIGQKIFL WSLRASELTG 1200
MAFIDTQLYI HQMISVKNFI LAADVMKSIS LLRYQEESKT LSLVSRDAKP LEVYSVDFMV 1260
DNAQLGFLVS DRDRNLMVYM YLPEAKESFG GMRLLRRADF HVGAHVNTFW RTPCRGAAEG 1320
PSKKSVVWEN KHITWFATLD GGIGLLLPMQ EKTYRRLLML QNALTTMLPH HAGLNPRAFR 1380
MLHVDRRILQ NAVRNVLDGE LLNRYLYLST MERSELAKKI GTTPDIILDD LLETDRVTAH 1440
F 1441 |
Gene Ontology | GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; ISS:UniProtKB. GO:0003730; F:mRNA 3'-UTR binding; IEA:Compara. GO:0006379; P:mRNA cleavage; IEA:Compara. GO:0006378; P:mRNA polyadenylation; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |