CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022905
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Secretion-regulating guanine nucleotide exchange factor 
Protein Synonyms/Alias
 Deafness locus-associated putative guanine nucleotide exchange factor; DelGEF; Guanine nucleotide exchange factor-related protein 
Gene Name
 SERGEF 
Gene Synonyms/Alias
 DELGEF; GNEFR 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
201LPLFFTAKEPSRVTGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process. 
Sequence Annotation
 REPEAT 15 67 RCC1 1.
 REPEAT 68 119 RCC1 2.
 REPEAT 120 171 RCC1 3.
 REPEAT 172 230 RCC1 4.
 REPEAT 231 283 RCC1 5.
 REPEAT 284 351 RCC1 6.
 REPEAT 352 402 RCC1 7.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Guanine-nucleotide releasing factor; Nucleus; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 458 AA 
Protein Sequence
MEREPSASEA APAAAALFAW GANSYGQLGL GHKEDVLLPQ QLNDFCKPRS VRRITGGGGH 60
SAVVTDGGDL FVCGLNKDGQ LGLGHTEDIP YFTPCKSLFG CPIQQVACGW DFTIMLTENG 120
QVLSCGSNSF GQLGVPHGPR RCVVPQAIEL HKEKVVCIAA GLRHAVAATA SGIVFQWGTG 180
LASCGRRLCP GQTLPLFFTA KEPSRVTGLE NSKAMCVLAG SDHSASLTDA GEVYVWGSNK 240
HGQLANEAAF LPVPQKIEAH CFQNEKVTAI WSGWTHLVAQ TETGKMFTWG RADYGQLGRK 300
LETYEGWKLE KQDSFLPCSR PPNSMPSSPH CLTGATEVSC GSEHNLAIIG GVCYSWGWNE 360
HGMCGDGTEA NVWAPKPVQA LLSSSGLLVG CGAGHSLALC QLPAHPALVQ DPKVTYLSPD 420
AIEDTESQKA MDKERNWKER QSETSTQSQS DWSRNGGL 458 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005087; F:Ran guanyl-nucleotide exchange factor activity; TAS:UniProtKB.
 GO:0050709; P:negative regulation of protein secretion; IDA:HGNC.
 GO:0007165; P:signal transduction; TAS:UniProtKB. 
Interpro
 IPR027048; DelGEF.
 IPR009091; RCC1/BLIP-II.
 IPR000408; Reg_chr_condens. 
Pfam
 PF00415; RCC1 
SMART
  
PROSITE
 PS00625; RCC1_1
 PS00626; RCC1_2
 PS50012; RCC1_3 
PRINTS
 PR00633; RCCNDNSATION.