CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031178
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Eukaryotic translation initiation factor 4B 
Protein Synonyms/Alias
 cDNA FLJ59405, highly similar to Eukaryotic translation initiation factor 4B 
Gene Name
 EIF4B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
138VADQAQDKDRDDRSFacetylation[1]
155DRNRDSDKTDTDWRAacetylation[1]
184GDDSFGDKYRDRYDSacetylation[1]
184GDDSFGDKYRDRYDSubiquitination[2]
326ASIFGGAKPVDTAARacetylation[1]
405ARRRESEKSLENETLacetylation[1]
547PEENPASKFSSASKYacetylation[1]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Initiation factor; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 572 AA 
Protein Sequence
MAASAKKKNK KGKTISLTDF LAEDGGTGGG STYVSKPVSW ADETDDLEGD VSTTWHSNDD 60
DVYRAPPIDR SILPTAPRAA REPNIDRSRL PKSPPYTAFL GNLPYDVTEE SIKEFFRGLN 120
SLGNRRIRVD VADQAQDKDR DDRSFGRDRN RDSDKTDTDW RARPATDSFD DYPPRRGDDS 180
FGDKYRDRYD SDRYRDGYRD GYRDGPRRDM DRYGGRDRYD DRGSRDYDRG YDSRIGSGRR 240
AFGSGYRRDD DYRGGGDRYE DRYDRRDDRS WSSRDDYSRD DYRRDDRGPP QRPKLNLKPR 300
STPKEDDSSA STSQSTRAAS IFGGAKPVDT AAREREVEER LQKEQEKLQR QLDEPKLERR 360
PRERHPSWRS EETQERERSR TGSESSQTGT STTSSRNARR RESEKSLENE TLNKEEDCHS 420
PTSKPPKPDQ PLKVMPAPPP KENAWVKRSS NPPARSQSSD TEQQSPTSGG GKVAPAQPSE 480
EGPGRKDENK VDGMNAPKGQ TGNSSRGPGD GGNRDHWKES DRKDGKKDQD SRSAPEPKKP 540
EENPASKFSS ASKYAALSVD GEDENEGEDY AE 572 
Gene Ontology
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait. 
Pfam
  
SMART
  
PROSITE
  
PRINTS