UniProt Accession

 LZTS2_HUMAN; Q9BRK4; B1AL14; D3DR72; Q8N3I0; Q96J79; Q96JL2 

Genbank Protein ID

 AB058716; AL133215; CH471066; CH471066; CH471066; BC006212; BC058938; AY029201; AL834338 

Genbank Nucleotide ID

 BAB47442.1; CAI10929.1; EAW49790.1; EAW49791.1; EAW49792.1; AAH06212.2; AAH58938.1; AAK31577.1; CAD39005.1 

Protein Name

 Leucine zipper putative tumor suppressor 2 

Protein Synonyms/Alias

 hLZTS2; Protein LAPSER1 

Gene Name

 LZTS2 

Gene Synonyms/Alias

 KIAA1813; LAPSER1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
607	RLAWQAEKEQVIRYQ	methylation	[1]
615	EQVIRYQKQLQHNYI	ubiquitination	[2, 3, 4]

Reference

 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. 

Sequence Annotation

 REGION 1 332 Required for centrosomal localization (By
 REGION 447 669 Sufficient for interaction with CTNNB1.
 REGION 450 669 Sufficient for interaction with KATNB1
 MOTIF 631 640 Nuclear export signal.
 MOD_RES 570 570 Phosphoserine.  

Keyword

 Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Mitosis; Phosphoprotein; Polymorphism; Reference proteome; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 669 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

  

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