UniProt Accession

 SGTA_MOUSE; Q8BJU0; Q8BGA6; Q99L52 

Genbank Protein ID

 AK039966; AK051005; AK079168; BC003836 

Genbank Nucleotide ID

 BAC30486.1; BAC34494.1; BAC37566.1; AAH03836.1 

Protein Name

 Small glutamine-rich tetratricopeptide repeat-containing protein alpha 

Protein Synonyms/Alias

 Alpha-SGT 

Gene Name

 Sgta 

Gene Synonyms/Alias

 Sgt 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
104	TEGNEQMKLENFEAA	acetylation	[1]
104	TEGNEQMKLENFEAA	ubiquitination	[2]
138	NRAAAYSKLGNYVGA	acetylation	[1, 3, 4]
138	NRAAAYSKLGNYVGA	ubiquitination	[2]
161	GIDPGYSKAYGRMGL	acetylation	[1, 3]
161	GIDPGYSKAYGRMGL	ubiquitination	[2]
175	LALSSLNKHAEAVAY	ubiquitination	[2]
185	EAVAYYKKALELDPD	ubiquitination	[2]
197	DPDNDTYKSNLKIAE	ubiquitination	[2]
201	DTYKSNLKIAELKLR	ubiquitination	[2]
206	NLKIAELKLREAPSP	ubiquitination	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity (By similarity). 

Sequence Annotation

 REPEAT 92 125 TPR 1.
 REPEAT 126 159 TPR 2.
 REPEAT 160 193 TPR 3.
 MOD_RES 82 82 Phosphothreonine.
 MOD_RES 138 138 N6-acetyllysine (By similarity).
 MOD_RES 303 303 Phosphoserine (By similarity).
 MOD_RES 305 305 Phosphothreonine (By similarity).
 MOD_RES 307 307 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Chaperone; Complete proteome; Phosphoprotein; Reference proteome; Repeat; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 315 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0046982; F:protein heterodimerization activity; ISA:MGI.
 GO:0042803; F:protein homodimerization activity; ISA:MGI. 

Interpro

 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

 PF00515; TPR_1 

SMART

 SM00028; TPR 

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS