UniProt Accession

 TISD_HUMAN; P47974; Q53TB4; Q9BSJ3 

Genbank Protein ID

 U07802; X78992; AC010883; CH471053; BC005010 

Genbank Nucleotide ID

 AAA91778.1; CAA55592.1; AAY14992.1; EAX00306.1; AAH05010.1 

Protein Name

 Zinc finger protein 36, C3H1 type-like 2 

Protein Synonyms/Alias

 ZFP36-like 2; Butyrate response factor 2; EGF-response factor 2; ERF-2; Protein TIS11D 

Gene Name

 ZFP36L2 

Gene Synonyms/Alias

 BRF2; ERF2; RNF162C; TIS11D 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
20	DFLCKTEKSLANLNL	ubiquitination	[1]
33	NLNNMLDKKAVGTPV	ubiquitination	[1]
34	LNNMLDKKAVGTPVA	ubiquitination	[1]
102	PTSYGTLKEPSGGGG	ubiquitination	[1]
142	LHLQQQQKGGGGSQI	ubiquitination	[1, 2, 3]
155	QINSTRYKTELCRPF	ubiquitination	[1]
173	GTCKYGEKCQFAHGF	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Probable regulatory protein involved in regulating the response to growth factors. RNA-binding protein that binds to 5'UUAUUUAUUU-3' core sequence. Binds to the class II AU-rich element (ARE) in the 3'-UTR of target mRNAs and promotes their deadenylation and degradation. 

Sequence Annotation

 ZN_FING 153 181 C3H1-type 1.
 ZN_FING 191 219 C3H1-type 2.
 REGION 170 211 RNA-binding.
 MOTIF 153 158 RNA-binding.
 MOD_RES 57 57 Phosphoserine.
 MOD_RES 125 125 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 494 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0000288; P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; IEA:Compara.
 GO:0043488; P:regulation of mRNA stability; IEA:Compara. 

Interpro

 IPR007635; Tis11B_N.
 IPR000571; Znf_CCCH. 

Pfam

 PF04553; Tis11B_N
 PF00642; zf-CCCH 

SMART

 SM00356; ZnF_C3H1 

PROSITE

 PS50103; ZF_C3H1 

PRINTS