CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001819
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fructose-bisphosphate aldolase B 
Protein Synonyms/Alias
 Liver-type aldolase 
Gene Name
 Aldob 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
13PALTSEQKKELSEIAacetylation[1]
14ALTSEQKKELSEIAQacetylation[1]
48GNRLQRIKVENTEENacetylation[1]
92YQKDSQGKLFRNILKacetylation[1]
101FRNILKEKGIVVGIKacetylation[1]
108KGIVVGIKLDQGGAPacetylation[1]
121APLAGTNKETTIQGLacetylation[1]
140ERCAQYKKDGVDFGKacetylation[1]
147KDGVDFGKWRAVLRIacetylation[1]
243AGHACTKKYTPEQVAacetylation[1]
330ATQEAFMKRAVANCQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 ACT_SITE 188 188 Proton acceptor (By similarity).
 ACT_SITE 230 230 Schiff-base intermediate with
 BINDING 56 56 Substrate.
 BINDING 147 147 Substrate.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 36 36 Phosphoserine (By similarity).  
Keyword
 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Glycolysis; Lyase; Phosphoprotein; Reference proteome; Schiff base. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 364 AA 
Protein Sequence
MAHRFPALTS EQKKELSEIA QRIVANGKGI LAADESVGTM GNRLQRIKVE NTEENRRQFR 60
ELLFSVDNSI SQSIGGVILF HETLYQKDSQ GKLFRNILKE KGIVVGIKLD QGGAPLAGTN 120
KETTIQGLDG LSERCAQYKK DGVDFGKWRA VLRISDQCPS SLAIQENANA LARYASICQQ 180
NGLVPIVEPE VLPDGDHDLE HCQYVSEKVL AAVYKALNDH HVYLEGTLLK PNMLTAGHAC 240
TKKYTPEQVA MATVTALHRT VPAAVPSICF LSGGMSEEDA TLNLNAIYRC PLPRPWKLSF 300
SYGRALQASA LAAWGGKAAN KKATQEAFMK RAVANCQAAQ GQYVHTGSSG AASTQSLFTA 360
SYTY 364 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005764; C:lysosome; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0030867; C:rough endoplasmic reticulum membrane; IDA:RGD.
 GO:0030868; C:smooth endoplasmic reticulum membrane; IDA:RGD.
 GO:0004332; F:fructose-bisphosphate aldolase activity; IDA:RGD.
 GO:0031210; F:phosphatidylcholine binding; IPI:RGD.
 GO:0031668; P:cellular response to extracellular stimulus; IEP:RGD.
 GO:0032869; P:cellular response to insulin stimulus; IEP:RGD.
 GO:0006096; P:glycolysis; IDA:RGD.
 GO:0001889; P:liver development; IEP:RGD.
 GO:0043200; P:response to amino acid stimulus; IEP:RGD.
 GO:0051591; P:response to cAMP; IEP:RGD.
 GO:0046688; P:response to copper ion; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0009750; P:response to fructose stimulus; IEP:RGD.
 GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.
 GO:0070741; P:response to interleukin-6; IEP:RGD.
 GO:0042594; P:response to starvation; IEP:RGD.
 GO:0010043; P:response to zinc ion; IDA:RGD. 
Interpro
 IPR000741; Aldolase_I.
 IPR013785; Aldolase_TIM. 
Pfam
 PF00274; Glycolytic 
SMART
  
PROSITE
 PS00158; ALDOLASE_CLASS_I 
PRINTS