CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001291
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Regulator of G-protein signaling 9 
Protein Synonyms/Alias
 RGS9 
Gene Name
 RGS9 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
409DSYARYLKSPIYKDMubiquitination[1]
419IYKDMLAKAIEPQETacetylation[2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity). 
Sequence Annotation
 DOMAIN 30 105 DEP.
 DOMAIN 219 280 G protein gamma.
 DOMAIN 298 413 RGS.  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Sensory transduction; Signal transduction inhibitor; Vision. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 674 AA 
Protein Sequence
MTIRHQGQQY RPRMAFLQKI EALVKDMQNP ETGVRMQNQR VLVTSVPHAM TGSDVLQWIV 60
QRLWISSLEA QNLGNFIVRY GYIYPLQDPK NLILKPDGSL YRFQTPYFWP TQQWPAEDTD 120
YAIYLAKRNI KKKGILEEYE KENYNFLNQK MNYKWDFVIM QAKEQYRAGK ERNKADRYAL 180
DCQEKAYWLV HRCPPGMDNV LDYGLDRVTN PNEVKVNQKQ TVVAVKKEIM YYQQALMRST 240
VKSSVSLGGI VKYSEQFSSN DAIMSGCLPS NPWITDDTQF WDLNAKLVEI PTKMRVERWA 300
FNFSELIRDP KGRQSFQYFL KKEFSGENLG FWEACEDLKY GDQSKVKEKA EEIYKLFLAP 360
GARRWINIDG KTMDITVKGL KHPHRYVLDA AQTHIYMLMK KDSYARYLKS PIYKDMLAKA 420
IEPQETTKKS STLPFMRRHL RSSPSPVILR QLEEEAKARE AANTVDITQP GQHMAPSPHL 480
TVYTGTCMPP SPSSPFSSSC RSPRKPFASP SRFIRRPSTT ICPSPIRVAL ESSSGLEQKG 540
ECSGSMAPRG PSVTESSEAS LDTSWPRSRP RAPPKARMAL SFSRFLRRGC LASPVFARLS 600
PKCPAVSHGR VQPLGDVGQQ LPRLKSKRVA NFFQIKMDVP TGSGTCLMDS EDAGTGESGD 660
RATEKEVICP WESL 674 
Gene Ontology
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; IBA:RefGenome.
 GO:0005096; F:GTPase activator activity; IBA:RefGenome.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0007212; P:dopamine receptor signaling pathway; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0007399; P:nervous system development; IEA:Compara.
 GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; TAS:ProtInc.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.
 GO:0007601; P:visual perception; IEA:UniProtKB-KW. 
Interpro
 IPR000591; DEP_dom.
 IPR015898; G-protein_gamma-like_dom.
 IPR000342; Regulat_G_prot_signal.
 IPR024066; Regulat_G_prot_signal_dom1.
 IPR016137; Regulat_G_prot_signal_superfam.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00610; DEP
 PF00631; G-gamma
 PF00615; RGS 
SMART
 SM00049; DEP
 SM00224; GGL
 SM00315; RGS 
PROSITE
 PS50186; DEP
 PS50058; G_PROTEIN_GAMMA
 PS50132; RGS 
PRINTS
 PR01301; RGSPROTEIN.