CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002525
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 L-aminoadipate-semialdehyde dehydrogenase 
Protein Synonyms/Alias
 Alpha-aminoadipate reductase; Alpha-AR 
Gene Name
 LYS2 
Gene Synonyms/Alias
 YBR115C; YBR0910 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
541FVGDILTKRDCLRLQubiquitination[1]
1130DKLVSEGKPGILESDubiquitination[1]
1276ESYSKWKKSLEASVIubiquitination[1]
Reference
 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 
Functional Description
 Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha- aminoadipate by NADPH. 
Sequence Annotation
 DOMAIN 848 917 Acyl carrier.
 MOD_RES 880 880 O-(pantetheine 4'-phosphoryl)serine.  
Keyword
 Amino-acid biosynthesis; Complete proteome; Lysine biosynthesis; NADP; Oxidoreductase; Phosphopantetheine; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1392 AA 
Protein Sequence
MTNEKVWIEK LDNPTLSVLP HDFLRPQQEP YTKQATYSLQ LPQLDVPHDS FSNKYAVALS 60
VWAALIYRVT GDDDIVLYIA NNKILRFNIQ PTWSFNELYS TINNELNKLN SIEANFSFDE 120
LAEKIQSCQD LERTPQLFRL AFLENQDFKL DEFKHHLVDF ALNLDTSNNA HVLNLIYNSL 180
LYSNERVTIV ADQFTQYLTA ALSDPSNCIT KISLITASSK DSLPDPTKNL GWCDFVGCIH 240
DIFQDNAEAF PERTCVVETP TLNSDKSRSF TYRDINRTSN IVAHYLIKTG IKRGDVVMIY 300
SSRGVDLMVC VMGVLKAGAT FSVIDPAYPP ARQTIYLGVA KPRGLIVIRA AGQLDQLVED 360
YINDELEIVS RINSIAIQEN GTIEGGKLDN GEDVLAPYDH YKDTRTGVVV GPDSNPTLSF 420
TSGSEGIPKG VLGRHFSLAY YFNWMSKRFN LTENDKFTML SGIAHDPIQR DMFTPLFLGA 480
QLYVPTQDDI GTPGRLAEWM SKYGCTVTHL TPAMGQLLTA QATTPFPKLH HAFFVGDILT 540
KRDCLRLQTL AENCRIVNMY GTTETQRAVS YFEVKSKNDD PNFLKKLKDV MPAGKGMLNV 600
QLLVVNRNDR TQICGIGEIG EIYVRAGGLA EGYRGLPELN KEKFVNNWFV EKDHWNYLDK 660
DNGEPWRQFW LGPRDRLYRT GDLGRYLPNG DCECCGRADD QVKIRGFRIE LGEIDTHISQ 720
HPLVRENITL VRKNADNEPT LITFMVPRFD KPDDLSKFQS DVPKEVETDP IVKGLIGYHL 780
LSKDIRTFLK KRLASYAMPS LIVVMDKLPL NPNGKVDKPK LQFPTPKQLN LVAENTVSET 840
DDSQFTNVER EVRDLWLSIL PTKPASVSPD DSFFDLGGHS ILATKMIFTL KKKLQVDLPL 900
GTIFKYPTIK AFAAEIDRIK SSGGSSQGEV VENVTANYAE DAKKLVETLP SSYPSREYFV 960
EPNSAEGKTT INVFVTGVTG FLGSYILADL LGRSPKNYSF KVFAHVRAKD EEAAFARLQK 1020
AGITYGTWNE KFASNIKVVL GDLSKSQFGL SDEKWMDLAN TVDIIIHNGA LVHWVYPYAK 1080
LRDPNVISTI NVMSLAAVGK PKFFDFVSST STLDTEYYFN LSDKLVSEGK PGILESDDLM 1140
NSASGLTGGY GQSKWAAEYI IRRAGERGLR GCIVRPGYVT GASANGSSNT DDFLLRFLKG 1200
SVQLGKIPDI ENSVNMVPVD HVARVVVATS LNPPKENELA VAQVTGHPRI LFKDYLYTLH 1260
DYGYDVEIES YSKWKKSLEA SVIDRNEENA LYPLLHMVLD NLPESTKAPE LDDRNAVASL 1320
KKDTAWTGVD WSNGIGVTPE EVGIYIAFLN KVGFLPPPTH NDKLPLPSIE LTQAQISLVA 1380
SGAGARGSSA AA 1392 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0004043; F:L-aminoadipate-semialdehyde dehydrogenase activity; IDA:SGD.
 GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
 GO:0019878; P:lysine biosynthetic process via aminoadipic acid; IDA:SGD. 
Interpro
 IPR010071; AA_adenyl_domain.
 IPR009081; Acyl_carrier_prot-like.
 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig.
 IPR014397; L-NH2adipate-semiAld_DH_lsu.
 IPR013120; Male_sterile_NAD-bd.
 IPR016040; NAD(P)-bd_dom.
 IPR006162; PPantetheine_attach_site.
 IPR010080; Thioester_reductase_dom. 
Pfam
 PF00501; AMP-binding
 PF07993; NAD_binding_4
 PF00550; PP-binding 
SMART
  
PROSITE
 PS50075; ACP_DOMAIN
 PS00455; AMP_BINDING
 PS00012; PHOSPHOPANTETHEINE 
PRINTS