UniProt Accession

 CSN7A_MOUSE; Q9CZ04; O88546; Q925R8; Q9CPQ4; Q9CWD2 

Genbank Protein ID

 AF071316; AK010726; AK013155; AK019122; BC003724; AF240179 

Genbank Nucleotide ID

 AAC33903.1; BAB27144.1; BAB28682.1; BAB31554.1; AAH03724.1; AAK43736.1 

Protein Name

 COP9 signalosome complex subunit 7a 

Protein Synonyms/Alias

 SGN7a; Signalosome subunit 7a; JAB1-containing signalosome subunit 7a 

Gene Name

 Cops7a 

Gene Synonyms/Alias

 Csn7a 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
20	EQFLLLAKSAKGAAL	ubiquitination	[1]
199	VSRANQHKEQQLGLK	ubiquitination	[1]
206	KEQQLGLKQQIESEV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). 

Sequence Annotation

 DOMAIN 52 156 PCI.
 MOD_RES 2 2 N-acetylserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Signalosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 275 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008180; C:signalosome; IEA:UniProtKB-KW.
 GO:0010388; P:cullin deneddylation; IEA:Compara. 

Interpro

 IPR000717; PCI_dom. 

Pfam

 PF01399; PCI 

SMART

 SM00088; PINT 

PROSITE

  

PRINTS