CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001168
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peroxisomal membrane protein PEX14 
Protein Synonyms/Alias
 PTS1 receptor-docking protein; Peroxin-14; Peroxisomal membrane anchor protein PEX14 
Gene Name
 PEX14 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
34PLIATAVKFLQNSRVacetylation[1]
34PLIATAVKFLQNSRVubiquitination[2, 3, 4]
213SQNINELKSEINSLKubiquitination[5]
220KSEINSLKGLLLNRRubiquitination[2, 4, 5]
363QINEQVEKLRRPEGAubiquitination[2, 4, 5]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17. 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 34 34 N6-acetyllysine.
 MOD_RES 335 335 Phosphoserine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Membrane; Peroxisome; Peroxisome biogenesis disorder; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Translocation; Transport; Zellweger syndrome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 377 AA 
Protein Sequence
MASSEQAEQP SQPSSTPGSE NVLPREPLIA TAVKFLQNSR VRQSPLATRR AFLKKKGLTD 60
EEIDMAFQQS GTAADEPSSL GPATQVVPVQ PPHLISQPYS PAGSRWRDYG ALAIIMAGIA 120
FGFHQLYKKY LLPLILGGRE DRKQLERMEA GLSELSGSVA QTVTQLQTTL ASVQELLIQQ 180
QQKIQELAHE LAAAKATTST NWILESQNIN ELKSEINSLK GLLLNRRQFP PSPSAPKIPS 240
WQIPVKSPSP SSPAAVNHHS SSDISPVSNE STSSSPGKEG HSPEGSTVTY HLLGPQEEGE 300
GVVDVKGQVR MEVQGEEEKR EDKEDEEDEE DDDVSHVDEE DCLGVQREDR RGGDGQINEQ 360
VEKLRRPEGA SNESERD 377 
Gene Ontology
 GO:0016021; C:integral to membrane; ISS:UniProtKB.
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0005778; C:peroxisomal membrane; IDA:UniProtKB.
 GO:0043234; C:protein complex; IDA:UniProtKB.
 GO:0008017; F:microtubule binding; IDA:UniProtKB.
 GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
 GO:0034453; P:microtubule anchoring; IDA:UniProtKB.
 GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
 GO:1901094; P:negative regulation of protein homotetramerization; IDA:UniProtKB.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0036250; P:peroxisome transport along microtubule; IDA:UniProtKB.
 GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
 GO:0044721; P:protein import into peroxisome matrix, substrate release; IDA:UniProtKB.
 GO:0016561; P:protein import into peroxisome matrix, translocation; IDA:UniProtKB. 
Interpro
 IPR025655; PEX14.
 IPR006785; Pex14_N. 
Pfam
 PF04695; Pex14_N 
SMART
  
PROSITE
  
PRINTS