| Tag | Content |
|---|
| CPLM ID | CPLM-009367 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein transport protein Sec61 subunit alpha isoform 1 |
Protein Synonyms/Alias | Sec61 alpha-1 |
Gene Name | SEC61A1 |
Gene Synonyms/Alias | SEC61A |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 4 | ****MAIKFLEVIKP | ubiquitination | [1] | | 10 | IKFLEVIKPFCVILP | ubiquitination | [1] | | 21 | VILPEIQKPERKIQF | ubiquitination | [1] | | 392 | SSAKDVAKQLKEQQM | ubiquitination | [1] | | 395 | KDVAKQLKEQQMVMR | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane- bound ribosomes, either directly or through adapter proteins. |
Sequence Annotation | |
Keyword | Alternative splicing; Complete proteome; Endoplasmic reticulum; Membrane; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 476 AA |
Protein Sequence | MAIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL FGIMSSDSAD 60
PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII EVGDTPKDRA LFNGAQKLFG 120
MIITIGQSIV YVMTGMYGDP SEMGAGICLL ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS 180
LFIATNICET IVWKAFSPTT VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP 240
NLMNLIATIF VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN 300
LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARAYPVGG LCYYLSPPES FGSVLEDPVH 360
AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV MRGHRETSMV HELNRYIPTA 420
AAFGGLCIGA LSVLADFLGA IGSGTGILLA VTIIYQYFEI FVKEQSEVGS MGALLF 476 |
Gene Ontology | GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:UniProtKB. GO:0005791; C:rough endoplasmic reticulum; IEA:Compara. GO:0043022; F:ribosome binding; ISS:UniProtKB. GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome. GO:0045047; P:protein targeting to ER; ISS:UniProtKB. GO:0034341; P:response to interferon-gamma; IEA:Compara. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |