CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024650
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 OTU domain-containing protein 4 
Protein Synonyms/Alias
  
Gene Name
 Otud4 
Gene Synonyms/Alias
 Kiaa1046 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
287LQYEVGDKCHQVRLDubiquitination[1]
329KHTPKNLKPPPPESWubiquitination[1]
342SWNTVSGKKMKKPNSacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
 DOMAIN 34 155 OTU.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 438 438 Phosphotyrosine.
 MOD_RES 442 442 Phosphoserine (By similarity).
 MOD_RES 459 459 Phosphotyrosine (By similarity).
 MOD_RES 895 895 Phosphoserine (By similarity).
 MOD_RES 1000 1000 Phosphoserine.
 MOD_RES 1005 1005 Phosphoserine.
 MOD_RES 1016 1016 Phosphoserine.
 MOD_RES 1017 1017 Phosphoserine.  
Keyword
 Acetylation; Complete proteome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1107 AA 
Protein Sequence
MEAAVGAPDG VDQGGVGPLE DETPMDAYLR KLGLYRKLVA KDGSCLFRAV AEQVLHSQSR 60
HVEVRMACIR YLRENREKFE AFIEGSFEEY LKRLENPQEW VGQVEISALS LMYRKDFVIY 120
QEPNVSPSHV TENNFPEKVL LCFSNGNHYD IVYPITYKDS SAMCQSLLYE LLYEKVFKTD 180
VSKIMMGLEA SEVAEESNSE ISDSEDDSCK SKSTAATDVN GFKPSGSENP KNNGNSADLP 240
LSRKVLKSLN PAVYRNVEYE IWLKSKQAQQ KRDYSIAAGL QYEVGDKCHQ VRLDHNGKLS 300
NADIHGVHSE NGLVLSEELG KKHTPKNLKP PPPESWNTVS GKKMKKPNSG QNFHSDTDYR 360
GPKNLNKPIK APSALPPRLQ HPSSGVRQHA FSSHSTGSQS QKSSSEHKNL SRMPSQITRK 420
PDRERAEDFD HVSRESYYFG LSPEERREKQ AIEESRLLYE IQNRDEQAFP ALSSSSVSQS 480
PSQNSNACVP RKSSHARDRK GSMRRADAEE RKDKDSLRGH THVDKKPEPS TLEISDDKCT 540
RVSSPSKSKK ECPSPVEQKP AEHIPLSNPA PLLVSPEVHL TPAVPSLPAT VPAWPSEPTT 600
FGPTGVPAQI PILSVTQTTG PDAAVSQAHL TPSPVPVSIQ AVNQPLMPLP QTMSLYQDPL 660
YPGFPCSEKG DRAIAPPYSL CQTGEDLPKD KNILRFFFNL GVKAYSCPMW APHSYLYPLH 720
QAYMAACRMY PKVPVPVYPQ NTWFQEAPPA QSESDCPCTD AHYSLHPEAS VNGQMPQAEM 780
GPPAFASPLV IPPSQVSEGH GQLSYQPELE SENPGQLLHA EYEESLSGKN MYPQQSFGPN 840
PFLGPVPIAP PFFPHVWYGY PFQGFVENPV MRQNIVLPPD DKGELDLPLE NLDLSKECDS 900
VSAVDEFPDA RVEGAHSLSA ASVSSKHEGR VEQSSQTRKA DIDLASGSSA VEGKGHPPTQ 960
ILNREREPGS AEPEPKRTIQ SLKEKPEKVK DPKTAADVVS PGANSVDRLQ RPKEESSEDE 1020
NEVSNILRSG RSKQFYNQTY GSRKYKSDWG SSGRGGYQHV RGEESWKGQP NRSRDEGYQY 1080
HRHVRGRPYR GDRRRSGMGD GHRGQHT 1107 
Gene Ontology
  
Interpro
 IPR003323; OTU. 
Pfam
 PF02338; OTU 
SMART
  
PROSITE
 PS50802; OTU 
PRINTS