| Tag | Content |
|---|
| CPLM ID | CPLM-000131 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Males-absent on the first protein |
Protein Synonyms/Alias | Histone acetyl transferase MOF |
Gene Name | mof |
Gene Synonyms/Alias | CG3025 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 483 | RQKRAANKDYYLSYC | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Histone acetyltransferase that plays a direct role in the specific histone acetylation associated with dosage compensation as part of the MSL complex. Dosage compensation insures that males with a single X chromosome have the same amount of most X-linked gene products as females with two X chromosomes. May be directly involved in the acetylation of histone 4 at 'Lys- 16' on the X chromosome of males where it is recruited by the MSL complex. As part of the NSL complex may associate with promoters of X chromosomal as well as autosomal genes and positively regulate their transcription through chromatin modification. |
Sequence Annotation | ZN_FING 572 594 C2HC-type.
REGION 370 443 Chromo barrel domain.
REGION 688 694 Acetyl-CoA binding (By similarity).
ACT_SITE 638 638 By similarity.
ACT_SITE 680 680 Nucleophile (By similarity).
BINDING 718 718 Acetyl-CoA (By similarity).
MOD_RES 638 638 N6-acetyllysine; by autocatalysis (By |
Keyword | 3D-structure; Acetylation; Acyltransferase; Chromatin regulator; Chromosome; Complete proteome; Metal-binding; Nucleus; Polymorphism; Reference proteome; Transferase; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 827 AA |
Protein Sequence | MSEAELEQTP SAGHVQEQPI EEEHEPEQEP TDAYTIGGPP RTPVEDAAAE LSASLDVSGS 60
DQSAEQSLDL SGVQAEAAAE SEPPAKRQHR DISPISEDST PASSTSTSST RSSSSSRYDD 120
VSEAEEAPPE PEPEQPQQQQ QEEKKEDGQD QVKSPGPVEL EAQEPAQPQK QKEVVDQEIE 180
TEDEPSSDTV ICVADINPYG SGSNIDDFVM DPDAPPNAII TEVVTIPAPL HLKGTQQLGL 240
PLAAPPPPPP PPAAEQVPET PASPTDDGEE PPAVYLSPYI RSRYMQESTP GLPTRLAPRD 300
PRQRNMPPPA VVLPIQTVLS ANVEAISDDS SETSSSDDDE EEEEDEDDAL TMEHDNTSRE 360
TVITTGDPLM QKIDISENPD KIYFIRREDG TVHRGQVLQS RTTENAAAPD EYYVHYVGLN 420
RRLDGWVGRH RISDNADDLG GITVLPAPPL APDQPSTSRE MLAQQAAAAA AASSERQKRA 480
ANKDYYLSYC ENSRYDYSDR KMTRYQKRRY DEINHVQKSH AELTATQAAL EKEHESITKI 540
KYIDKLQFGN YEIDTWYFSP FPEEYGKART LYVCEYCLKY MRFRSSYAYH LHECDRRRPP 600
GREIYRKGNI SIYEVNGKEE SLYCQLLCLM AKLFLDHKVL YFDMDPFLFY ILCETDKEGS 660
HIVGYFSKEK KSLENYNVAC ILVLPPHQRK GFGKLLIAFS YELSRKEGVI GSPEKPLSDL 720
GRLSYRSYWA YTLLELMKTR CAPEQITIKE LSEMSGITHD DIIYTLQSMK MIKYWKGQNV 780
ICVTSKTIQD HLQLPQFKQP KLTIDTDYLV WSPQTAAAVV RAPGNSG 827 |
Gene Ontology | GO:0005667; C:transcription factor complex; IDA:FlyBase. GO:0016456; C:X chromosome located dosage compensation complex, transcription activating; IDA:FlyBase. GO:0003682; F:chromatin binding; IDA:FlyBase. GO:0046972; F:histone acetyltransferase activity (H4-K16 specific); TAS:FlyBase. GO:0004468; F:lysine N-acetyltransferase activity; TAS:FlyBase. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0003729; F:mRNA binding; TAS:FlyBase. GO:0009047; P:dosage compensation by hyperactivation of X chromosome; NAS:FlyBase. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |