CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018910
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Exostosin-2 
Protein Synonyms/Alias
 Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Multiple exostoses protein 2; Putative tumor suppressor protein EXT2 
Gene Name
 EXT2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
168NQNTLRIKETAQAMAubiquitination[1]
245AEVDLPEKGPGPRQYubiquitination[1]
369SVVVPEEKMSDVYSIubiquitination[1]
488RVITEVSKVPSLSKLubiquitination[1]
504VVWNNQNKNPPEDSLubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. 
Sequence Annotation
 CARBOHYD 288 288 N-linked (GlcNAc...) (Potential).
 CARBOHYD 637 637 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Golgi apparatus; Hereditary multiple exostoses; Membrane; Polymorphism; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix; Tumor suppressor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 718 AA 
Protein Sequence
MCASVKYNIR GPALIPRMKT KHRIYYITLF SIVLLGLIAT GMFQFWPHSI ESSNDWNVEK 60
RSIRDVPVVR LPADSPIPER GDLSCRMHTC FDVYRCGFNP KNKIKVYIYA LKKYVDDFGV 120
SVSNTISREY NELLMAISDS DYYTDDINRA CLFVPSIDVL NQNTLRIKET AQAMAQLSRW 180
DRGTNHLLFN MLPGGPPDYN TALDVPRDRA LLAGGGFSTW TYRQGYDVSI PVYSPLSAEV 240
DLPEKGPGPR QYFLLSSQVG LHPEYREDLE ALQVKHGESV LVLDKCTNLS EGVLSVRKRC 300
HKHQVFDYPQ VLQEATFCVV LRGARLGQAV LSDVLQAGCV PVVIADSYIL PFSEVLDWKR 360
ASVVVPEEKM SDVYSILQSI PQRQIEEMQR QLFMEPARRE NWSAANHQMN SLIWPREQWD 420
SQIINDRIYP YAAISYEEWN DPPAVKWGSV SNPLFLPLIP PQSQGFTAIV LTYDRVESLF 480
RVITEVSKVP SLSKLLVVWN NQNKNPPEDS LWPKIRVPLK VVRTAENKLS NRFFPYDEIE 540
TEAVLAIDDD IIMLTSDELQ FGYEVWREFP DRLVGYPGRL HLWDHEMNKW KYESEWTNEV 600
SMVLTGAAFY HKYFNYLYTY KMPGDIKNWV DAHMNCEDIA MNFLVANVTG KAVIKVTPRK 660
KFKCPECTAI DGLSLDQTHM VERSECINKF ASVFGTMPLK VVEHRADPVL YKDDFPEKLK 720
SFPNIGSL 728 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; TAS:ProtInc.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031227; C:intrinsic to endoplasmic reticulum membrane; IEA:InterPro.
 GO:0050508; F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; IEA:EC.
 GO:0042328; F:heparan sulfate N-acetylglucosaminyltransferase activity; NAS:BHF-UCL.
 GO:0050509; F:N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity; NAS:BHF-UCL.
 GO:0006024; P:glycosaminoglycan biosynthetic process; IDA:BHF-UCL.
 GO:0015014; P:heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; IMP:BHF-UCL.
 GO:0001503; P:ossification; IMP:BHF-UCL.
 GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
 GO:0007165; P:signal transduction; TAS:ProtInc. 
Interpro
 IPR004263; Exostosin.
 IPR015338; HexNAc_Trfase_a. 
Pfam
 PF03016; Exostosin
 PF09258; Glyco_transf_64 
SMART
  
PROSITE
  
PRINTS