UniProt Accession

 PAIRB_HUMAN; Q8NC51; Q5VU19; Q5VU20; Q5VU22; Q8WUH0; Q96SE2; Q9BTY3; Q9BUM4; Q9Y367; Q9Y4S3 

Genbank Protein ID

 AF151813; AL080119; AK074970; CR457383; AL590559; AL590559; AL590559; BC003049; BC008045; BC017449; BC019273; BC020555; BC002488; BC026916; AY032853 

Genbank Nucleotide ID

 AAD34050.1; CAB45718.1; BAC11324.1; CAG33664.1; CAH73323.1; CAH73324.1; CAH73326.1; AAH03049.1; AAH08045.1; AAH17449.1; AAH19273.1; AAH20555.1; AAH02488.1; AAH26916.1; AAK51130.1 

Protein Name

 Plasminogen activator inhibitor 1 RNA-binding protein 

Protein Synonyms/Alias

 PAI1 RNA-binding protein 1; PAI-RBP1; SERPINE1 mRNA-binding protein 1 

Gene Name

 SERBP1 

Gene Synonyms/Alias

 PAIRBP1; CGI-55 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
68	TNSNAAGKQLRKESQ	ubiquitination	[1]
122	QQLQGEGKIIDRRPE	ubiquitination	[1]
211	FSHYSGLKHEDKRGG	ubiquitination	[1]
279	EMTLDEWKAIQNKDR	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. 

Sequence Annotation

 MOD_RES 25 25 Phosphoserine.
 MOD_RES 68 68 N6-acetyllysine.
 MOD_RES 122 122 N6-acetyllysine.
 MOD_RES 140 140 N6-acetyllysine.
 MOD_RES 211 211 N6-acetyllysine.
 MOD_RES 234 234 Phosphoserine.
 MOD_RES 244 244 Phosphotyrosine (By similarity).
 MOD_RES 252 252 Phosphoserine (By similarity).
 MOD_RES 330 330 Phosphoserine.
 MOD_RES 391 391 Phosphoserine (By similarity).
 MOD_RES 392 392 Phosphoserine.
 MOD_RES 394 394 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 408 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0003730; F:mRNA 3'-UTR binding; IDA:HGNC.
 GO:0043488; P:regulation of mRNA stability; NAS:HGNC. 

Interpro

 IPR006861; HABP4_PAIRBP1-bd.
 IPR027205; SERBP1. 

Pfam

 PF04774; HABP4_PAI-RBP1 

SMART

  

PROSITE

  

PRINTS