UniProt Accession

 RCBT1_HUMAN; Q8NDN9; Q8IY29; Q969U9 

Genbank Protein ID

 AF334406; AJ319660; AK096654; AL833821; AL139321; BC038104 

Genbank Nucleotide ID

 AAK38372.1; CAC40027.1; BAC04833.1; CAD38683.1; CAH71047.1; AAH38104.1 

Protein Name

 RCC1 and BTB domain-containing protein 1 

Protein Synonyms/Alias

 Chronic lymphocytic leukemia deletion region gene 7 protein; CLL deletion region gene 7 protein; Regulator of chromosome condensation and BTB domain-containing protein 1 

Gene Name

 RCBTB1 

Gene Synonyms/Alias

 CLLD7; E4.5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
67	QSTLVPKKLEGLCGK	ubiquitination	[1]
283	PAHIMVEKERVVEIA	ubiquitination	[1, 2, 3]
361	LTVAESLKKEFDSPE	ubiquitination	[2]
373	SPETADLKFRIDGKY	ubiquitination	[3]
464	KLCQHIIKRGITVEN	ubiquitination	[1]
522	LLKEFIAKASKCGAF	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May be involved in cell cycle regulation by chromatin remodeling. 

Sequence Annotation

 REPEAT 40 91 RCC1 1.
 REPEAT 93 145 RCC1 2.
 REPEAT 147 198 RCC1 3.
 REPEAT 199 250 RCC1 4.
 REPEAT 252 302 RCC1 5.
 REPEAT 304 356 RCC1 6.
 DOMAIN 370 437 BTB 1.
 DOMAIN 470 499 BTB 2.  

Keyword

 Alternative splicing; Cell cycle; Chromatin regulator; Complete proteome; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 531 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:LIFEdb.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR009091; RCC1/BLIP-II.
 IPR000408; Reg_chr_condens. 

Pfam

 PF00651; BTB
 PF00415; RCC1 

SMART

 SM00225; BTB 

PROSITE

 PS50097; BTB
 PS00625; RCC1_1
 PS00626; RCC1_2
 PS50012; RCC1_3 

PRINTS

 PR00633; RCCNDNSATION.