CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023143
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aspartyl aminopeptidase 
Protein Synonyms/Alias
  
Gene Name
 DNPEP 
Gene Synonyms/Alias
 ASPEP; DAP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23TAAKELLKFVNRSPSacetylation[1]
399REVANKVKVPLQDLMubiquitination[2]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism. 
Sequence Annotation
 METAL 94 94 Zinc 1.
 METAL 264 264 Zinc 1.
 METAL 264 264 Zinc 2.
 METAL 302 302 Zinc 2.
 METAL 346 346 Zinc 1.
 METAL 440 440 Zinc 2.
 BINDING 170 170 Substrate.
 BINDING 301 301 Substrate.
 BINDING 346 346 Substrate.
 BINDING 349 349 Substrate.
 BINDING 374 374 Substrate.
 BINDING 381 381 Substrate.  
Keyword
 3D-structure; Aminopeptidase; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 475 AA 
Protein Sequence
MQVAMNGKAR KEAVQTAAKE LLKFVNRSPS PFHAVAECRN RLLQAGFSEL KETEKWNIKP 60
ESKYFMTRNS STIIAFAVGG QYVPGNGFSL IGAHTDSPCL RVKRRSRRSQ VGFQQVGVET 120
YGGGIWSTWF DRDLTLAGRV IVKCPTSGRL EQQLVHVERP ILRIPHLAIH LQRNINENFG 180
PNTEMHLVPI LATAIQEELE KGTPEPGPLN AVDERHHSVL MSLLCAHLGL SPKDIVEMEL 240
CLADTQPAVL GGAYDEFIFA PRLDNLHSCF CALQALIDSC AGPGSLATEP HVRMVTLYDN 300
EEVGSESAQG AQSLLTELVL RRISASCQHP TAFEEAIPKS FMISADMAHA VHPNYLDKHE 360
ENHRPLFHKG PVIKVNSKQR YASNAVSEAL IREVANKVKV PLQDLMVRND TPCGTTIGPI 420
LASRLGLRVL DLGSPQLAMH SIREMACTTG VLQTLTLFKG FFELFPSLSH NLLVD 475 
Gene Ontology
 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0004177; F:aminopeptidase activity; TAS:ProtInc.
 GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006518; P:peptide metabolic process; TAS:ProtInc.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001948; Peptidase_M18.
 IPR023358; Peptidase_M18_dom2. 
Pfam
 PF02127; Peptidase_M18 
SMART
  
PROSITE
  
PRINTS
 PR00932; AMINO1PTASE.