CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002489
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Chemotaxis response regulator protein-glutamate methylesterase 
Protein Synonyms/Alias
  
Gene Name
 cheB 
Gene Synonyms/Alias
 b1883; JW1872 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
205SFADRLNKLCQIGVKacetylation[1]
246SGANYQIKIHDGPAVacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. 
Sequence Annotation
 DOMAIN 5 122 Response regulatory.
 DOMAIN 152 344 CheB-type methylesterase.
 ACT_SITE 164 164 By similarity.
 ACT_SITE 190 190 By similarity.
 ACT_SITE 286 286 By similarity.
 MOD_RES 56 56 4-aspartylphosphate (By similarity).  
Keyword
 Chemotaxis; Complete proteome; Cytoplasm; Hydrolase; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 349 AA 
Protein Sequence
MSKIRVLSVD DSALMRQIMT EIINSHSDME MVATAPDPLV ARDLIKKFNP DVLTLDVEMP 60
RMDGLDFLEK LMRLRPMPVV MVSSLTGKGS EVTLRALELG AIDFVTKPQL GIREGMLAYN 120
EMIAEKVRTA AKASLAAHKP LSAPTTLKAG PLLSSEKLIA IGASTGGTEA IRHVLQPLPL 180
SSPALLITQH MPPGFTRSFA DRLNKLCQIG VKEAEDGERV LPGHAYIAPG DRHMELSRSG 240
ANYQIKIHDG PAVNRHRPSV DVLFHSVAKQ AGRNAVGVIL TGMGNDGAAG MLAMRQAGAW 300
TLAQNEASCV VFGMPREAIN MGGVCEVVDL SQVSQQMLAK ISAGQAIRI 349 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
 GO:0008984; F:protein-glutamate methylesterase activity; IEA:HAMAP.
 GO:0006935; P:chemotaxis; IMP:EcoliWiki.
 GO:0035556; P:intracellular signal transduction; IEA:GOC.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
 GO:0007606; P:sensory perception of chemical stimulus; IEA:HAMAP. 
Interpro
 IPR011006; CheY-like_superfamily.
 IPR008248; Sig_transdc_resp-reg_CheB.
 IPR000673; Sig_transdc_resp-reg_Me-estase.
 IPR001789; Sig_transdc_resp-reg_receiver. 
Pfam
 PF01339; CheB_methylest
 PF00072; Response_reg 
SMART
 SM00448; REC 
PROSITE
 PS50122; CHEB
 PS50110; RESPONSE_REGULATORY 
PRINTS