CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027353
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine hydroxymethyltransferase 
Protein Synonyms/Alias
  
Gene Name
 PFL1720w 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
407LTDELQQKYGKKLVDacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 442 AA 
Protein Sequence
MFNNDPLQKY DKELFDLLEK EKNRQIETIN LIASENLTNT AVRECLGDRI SNKYSEGYPH 60
KRYYGGNDYV DKIEELCYKR ALEAFNVSEE EWGVNVQPLS GSAANVQALY ALVGVKGKIM 120
GMHLCSGGHL THGFFDEKKK VSITSDLFES KLYKCNSEGY VDMESVRNLA LSFQPKVIIC 180
GYTSYPRDID YKGFREICDE VNAYLFADIS HISSFVACNL LNNPFTYADV VTTTTHKILR 240
GPRSALIFFN KKRNPGIDQK INSSVFPSFQ GGPHNNKIAA VACQLKEVNT PFFKEYTKQV 300
LLNSKALAEC LLKRNLDLVT NGTDNHLIVV DLRKYNITGS KLQETCNAIN IALNKNTIPS 360
DVDCVSPSGI RIGTPALTTR GCKEKDMEFI ADMLLKAILL TDELQQKYGK KLVDFKKGLV 420
NNPKIDELKK EVVQWAKNLP FA 442 
Gene Ontology
 GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006544; P:glycine metabolic process; IEA:InterPro.
 GO:0006563; P:L-serine metabolic process; IEA:InterPro.
 GO:0006730; P:one-carbon metabolic process; TAS:GeneDB_Pfalciparum. 
Interpro
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR001085; Ser_HO-MeTrfase. 
Pfam
 PF00464; SHMT 
SMART
  
PROSITE
  
PRINTS