CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008308
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peroxisomal targeting signal 1 receptor 
Protein Synonyms/Alias
 PTS1 receptor; PTS1R; PTS1-BP; Peroxin-5; Peroxisomal C-terminal targeting signal import receptor; Peroxisome receptor 1 
Gene Name
 PEX5 
Gene Synonyms/Alias
 PXR1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
98SRAPQTFKMDDLLAEubiquitination[1]
224VAKVDDPKLANSEFLubiquitination[1]
232LANSEFLKFVRQIGEubiquitination[1]
471GAGLGPSKRILGSLLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. 
Sequence Annotation
 REPEAT 335 368 TPR 1.
 REPEAT 369 402 TPR 2.
 REPEAT 403 436 TPR 3.
 REPEAT 452 485 TPR 4.
 REPEAT 488 521 TPR 5.
 REPEAT 522 555 TPR 6.
 REPEAT 556 589 TPR 7.
 CROSSLNK 11 11 Glycyl cysteine thioester (Cys-Gly)  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; Membrane; Peroxisome; Peroxisome biogenesis disorder; Protein transport; Reference proteome; Repeat; Thioester bond; TPR repeat; Transport; Ubl conjugation; Zellweger syndrome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 639 AA 
Protein Sequence
MAMRELVEAE CGGANPLMKL AGHFTQDKAL RQEGLRPGPW PPGAPASEAV SVLEVESPGA 60
ASEAASKPLG VASEDELVAE FLQDQNAPLV SRAPQTFKMD DLLAEMQQIE QSNFRQAPQR 120
APGVADLALS ENWAQEFLAA GDAVDVTQDY NETDWSQEFI SEVTDPLSVS PARWAEEYLE 180
QSEEKLWLGE PEGTATDRWY DEYHPEEDLQ HTASDFVAKV DDPKLANSEF LKFVRQIGEG 240
QVSLESGAGS GRAQAEQWAA EFIQQQGTSD AWVDQFTRPV NTSALDMEFE RAKSAIESDV 300
DFWDKLQAEL EEMAKRDAEA HPWLSDYDDL TSATYDKGYQ FEEENPLRDH PQPFEEGLRR 360
LQEGDLPNAV LLFEAAVQQD PKHMEAWQYL GTTQAENEQE LLAISALRRC LELKPDNQTA 420
LMALAVSFTN ESLQRQACET LRDWLRYTPA YAHLVTPAEE GAGGAGLGPS KRILGSLLSD 480
SLFLEVKELF LAAVRLDPTS IDPDVQCGLG VLFNLSGEYD KAVDCFTAAL SVRPNDYLLW 540
NKLGATLANG NQSEEAVAAY RRALELQPGY IRSRYNLGIS CINLGAHREA VEHFLEALNM 600
QRKSRGPRGE GGAMSENIWS TLRLALSMLG QSDAYGAADA RDLSTLLTMF GLPQ 654 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005782; C:peroxisomal matrix; IDA:UniProtKB.
 GO:0005778; C:peroxisomal membrane; IDA:UniProtKB.
 GO:0043234; C:protein complex; IDA:UniProtKB.
 GO:0005052; F:peroxisome matrix targeting signal-1 binding; IDA:UniProtKB.
 GO:0048468; P:cell development; IEA:Compara.
 GO:0021795; P:cerebral cortex cell migration; IEA:Compara.
 GO:0021895; P:cerebral cortex neuron differentiation; IEA:Compara.
 GO:0007029; P:endoplasmic reticulum organization; IEA:Compara.
 GO:0006635; P:fatty acid beta-oxidation; IEA:Compara.
 GO:0007006; P:mitochondrial membrane organization; IEA:Compara.
 GO:1901094; P:negative regulation of protein homotetramerization; IDA:UniProtKB.
 GO:0050905; P:neuromuscular process; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0040018; P:positive regulation of multicellular organism growth; IEA:Compara.
 GO:0016558; P:protein import into peroxisome matrix; IGI:UniProtKB.
 GO:0016560; P:protein import into peroxisome matrix, docking; IDA:UniProtKB.
 GO:0016561; P:protein import into peroxisome matrix, translocation; IDA:UniProtKB.
 GO:0045046; P:protein import into peroxisome membrane; IMP:UniProtKB.
 GO:0051262; P:protein tetramerization; IDA:UniProtKB.
 GO:0000038; P:very long-chain fatty acid metabolic process; IEA:Compara. 
Interpro
 IPR024111; PTS1R_family.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00515; TPR_1 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS