| Tag | Content |
|---|
| CPLM ID | CPLM-022333 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Palmitoyltransferase ZDHHC7 |
Protein Synonyms/Alias | Zinc finger DHHC domain-containing protein 7; DHHC-7; Zinc finger protein 370 |
Gene Name | ZDHHC7 |
Gene Synonyms/Alias | ZNF370 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 176 | CPKCCCIKPERAHHC | ubiquitination | [1] | | 293 | ETEIERLKSEKPTWE | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors. |
Sequence Annotation | ZN_FING 130 180 DHHC-type. |
Keyword | Acyltransferase; Alternative splicing; Complete proteome; Golgi apparatus; Membrane; Metal-binding; Polymorphism; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 308 AA |
Protein Sequence | MQPSGHRLRD VEHHPLLAEN DNYDSSSSSS SEADVADRVW FIRDGCGMIC AVMTWLLVAY 60
ADFVVTFVML LPSKDFWYSV VNGVIFNCLA VLALSSHLRT MLTDPEKSSD CRPSACTVKT 120
GLDPTLVGIC GEGTESVQSL LLGAVPKGNA TKEYMESLQL KPGEVIYKCP KCCCIKPERA 180
HHCSICKRCI RKMDHHCPWV NNCVGEKNQR FFVLFTMYIA LSSVHALILC GFQFISCVRG 240
QWTECSDFSP PITVILLIFL CLEGLLFFTF TAVMFGTQIH SICNDETEIE RLKSEKPTWE 300
RRLRWEGMKS VFGGPPSLLW MNPFVGFRFR RLPTRPRKGG PEFSV 345 |
Gene Ontology | GO:0005794; C:Golgi apparatus; IDA:UniProtKB. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016409; F:palmitoyltransferase activity; IEA:Compara. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |