UniProt Accession

 EST3A_MOUSE; Q63880; Q3UEJ0; Q3UU08; Q6P8Z0; Q6PG74; Q810S9 

Genbank Protein ID

 S64130; AK138932; AK149499; BC048380; BC057187; BC057188; BC061004 

Genbank Nucleotide ID

 AAB27606.1; BAE23821.1; BAE28921.1; AAH48380.1; AAH57187.1; AAH57188.1; AAH61004.2 

Protein Name

 Carboxylesterase 3A 

Protein Synonyms/Alias

 ES-male; Liver carboxylesterase 31; Esterase-31 

Gene Name

 Ces3a 

Gene Synonyms/Alias

 Es31 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
54	RGRQVGVKDTDRMVN	acetylation	[1]
117	SRFTLNEKMKIFPIS	ubiquitination	[2]
302	CLLQKEGKDLITKKN	acetylation	[1]
307	EGKDLITKKNVNISY	acetylation	[1]
450	HTPSSFAKFKPAWVK	acetylation	[3]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. 

Sequence Annotation

 MOTIF 568 571 Prevents secretion from ER (Potential).
 ACT_SITE 232 232 Acyl-ester intermediate (By similarity).
 ACT_SITE 347 347 Charge relay system (By similarity).
 ACT_SITE 460 460 Charge relay system (By similarity).
 CARBOHYD 311 311 N-linked (GlcNAc...) (Potential).
 CARBOHYD 317 317 N-linked (GlcNAc...) (Potential).
 CARBOHYD 398 398 N-linked (GlcNAc...) (Potential).
 DISULFID 100 127 By similarity.
 DISULFID 284 295 By similarity.  

Keyword

 Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Hydrolase; Reference proteome; Serine esterase; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 571 AA 

Protein Sequence

Gene Ontology

 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0004091; F:carboxylesterase activity; IBA:RefGenome.
 GO:0080030; F:methyl indole-3-acetate esterase activity; IEA:EC.
 GO:0080032; F:methyl jasmonate esterase activity; IEA:EC.
 GO:0080031; F:methyl salicylate esterase activity; IEA:EC.
 GO:0050253; F:retinyl-palmitate esterase activity; IEA:EC. 

Interpro

 IPR002018; CarbesteraseB.
 IPR019826; Carboxylesterase_B_AS.
 IPR019819; Carboxylesterase_B_CS. 

Pfam

 PF00135; COesterase 

SMART

  

PROSITE

 PS00122; CARBOXYLESTERASE_B_1
 PS00941; CARBOXYLESTERASE_B_2 

PRINTS