UniProt Accession

 TTC8_MOUSE; Q8VD72; Q9DCP7 

Genbank Protein ID

 AK002597; AK081697; BC017523 

Genbank Nucleotide ID

 BAB22218.1; BAC38298.1; AAH17523.1 

Protein Name

 Tetratricopeptide repeat protein 8 

Protein Synonyms/Alias

 TPR repeat protein 8; Bardet-Biedl syndrome 8 protein homolog 

Gene Name

 Ttc8 

Gene Synonyms/Alias

 Bbs8 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
33	LCTQMLEKSPYDQAA	phosphoglycerylation	[1]

Reference

 [1] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237] 

Functional Description

 The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane (By similarity). 

Sequence Annotation

 REPEAT 4 37 TPR 1.
 REPEAT 225 258 TPR 2.
 REPEAT 259 291 TPR 3.
 REPEAT 292 325 TPR 4.
 REPEAT 326 359 TPR 5.
 REPEAT 360 393 TPR 6.
 REPEAT 397 430 TPR 7.
 REPEAT 432 464 TPR 8.  

Keyword

 Alternative splicing; Cell membrane; Cell projection; Cilium; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Reference proteome; Repeat; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 515 AA 

Protein Sequence

Gene Ontology

 GO:0034464; C:BBSome; IDA:MGI.
 GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
 GO:0060170; C:cilium membrane; IEA:UniProtKB-SubCell.
 GO:0005932; C:microtubule basal body; IEA:Compara.
 GO:0032391; C:photoreceptor connecting cilium; IDA:BHF-UCL.
 GO:0007411; P:axon guidance; IGI:MGI.
 GO:0060219; P:camera-type eye photoreceptor cell differentiation; IMP:MGI.
 GO:0042384; P:cilium assembly; IMP:MGI.
 GO:0048560; P:establishment of anatomical structure orientation; IEA:Compara.
 GO:0045444; P:fat cell differentiation; IEP:BHF-UCL.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0021772; P:olfactory bulb development; IMP:MGI.
 GO:0032880; P:regulation of protein localization; IMP:MGI.
 GO:0061326; P:renal tubule development; IMP:MGI.
 GO:0007608; P:sensory perception of smell; IMP:MGI. 

Interpro

 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 

Pfam

 PF07719; TPR_2 

SMART

 SM00028; TPR 

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS