UniProt Accession

 PFD3_YEAST; P48363; D6VUL0 

Genbank Protein ID

 U29137; Z72863; AY557774; BK006941 

Genbank Nucleotide ID

 AAA70038.1; CAA97080.1; AAS56100.1; DAA08171.1 

Protein Name

 Prefoldin subunit 3 

Protein Synonyms/Alias

 Genes involved in microtubule biogenesis protein 2; Gim complex subunit 2; GimC subunit 2 

Gene Name

 PAC10 

Gene Synonyms/Alias

 GIM2; PFD3; YGR078C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
55	YKFMQESKLATIKQL	acetylation	[1]
55	YKFMQESKLATIKQL	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. 

Sequence Annotation

  

Keyword

 Chaperone; Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 199 AA 

Protein Sequence

Gene Ontology

 GO:0005844; C:polysome; IDA:SGD.
 GO:0016272; C:prefoldin complex; IPI:SGD.
 GO:0015631; F:tubulin binding; IDA:SGD.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0007021; P:tubulin complex assembly; IMP:SGD. 

Interpro

 IPR009053; Prefoldin.
 IPR016655; Prefoldin_su-3.
 IPR004127; Prefoldin_subunit. 

Pfam

 PF02996; Prefoldin 

SMART

  

PROSITE

  

PRINTS