UniProt Accession

 B4E2I7_HUMAN; B4E2I7 

Genbank Protein ID

 AC008781; AK304291 

Genbank Nucleotide ID

 BAG65149.1 

Protein Name

 Protein diaphanous homolog 1 

Protein Synonyms/Alias

 cDNA FLJ61549, highly similar to Protein diaphanous homolog 1 

Gene Name

 DIAPH1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
35	SAGGDGGKSKKFTLK	ubiquitination	[1, 2]
133	SQYLYTSKAGMSQKE	ubiquitination	[3]
196	ASLLDILKRLHDD**	ubiquitination	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 201 AA 

Protein Sequence

Gene Ontology

 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro. 

Interpro

 IPR016024; ARM-type_fold.
 IPR010473; Drf_GTPase-bd.
 IPR014768; GTPase-bd/formin_homology_3. 

Pfam

 PF06371; Drf_GBD 

SMART

  

PROSITE

 PS51232; GBD_FH3 

PRINTS