| Tag | Content |
|---|
| CPLM ID | CPLM-007664 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Aldehyde dehydrogenase family 3 member B1 |
Protein Synonyms/Alias | Aldehyde dehydrogenase 7 |
Gene Name | ALDH3B1 |
Gene Synonyms/Alias | ALDH7 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 41 | GRFLQENKQLLHDAL | ubiquitination | [1] | | 252 | LGRIINQKQFQRLRA | ubiquitination | [1] | | 338 | SNSSQVVKRVLTQTS | ubiquitination | [1] | | 400 | LRSPGMEKLNALRYP | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation. |
Sequence Annotation | NP_BIND 188 193 NAD (By similarity).
ACT_SITE 210 210 By similarity.
ACT_SITE 244 244 By similarity. |
Keyword | Alternative splicing; Complete proteome; NAD; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 468 AA |
Protein Sequence | MDPLGDTLRR LREAFHAGRT RPAEFRAAQL QGLGRFLQEN KQLLHDALAQ DLHKATQLDS 60
AFIRKEPFGL VLIIAPWNYP LNLTLVPLVG ALAAGNCVVL KPSEISKNVE KILAEVLPQY 120
VDQSCFAVVL GGPQETGQLL EHRFDYIFFT GSPRVGKIVM TAAAKHLTPV TLELGGKNPC 180
YVDDNCDPQT VANRVAWFRY FNAGQTCVAP DYVLCSPEMQ ERLLPALQST ITRFYGDDPQ 240
SSPNLGRIIN QKQFQRLRAL LGCGRVAIGG QSDESDRYIA PTVLVDVQEM EPVMQEEIFG 300
PILPIVNVQS LDEAIEFINR REKPLALYAF SNSSQVVKRV LTQTSSGGFC GNDGFMHMTL 360
ASLPFGGVGA SGMGRYHGKF SFDTFSHHRA CLLRSPGMEK LNALRYPPQS PRRLRMLLVA 420
MEAQGCSCTL L 431 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:MGI. GO:0004028; F:3-chloroallyl aldehyde dehydrogenase activity; TAS:ProtInc. GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IDA:MGI. GO:0006066; P:alcohol metabolic process; TAS:ProtInc. GO:0046185; P:aldehyde catabolic process; IDA:MGI. GO:0034599; P:cellular response to oxidative stress; IDA:MGI. GO:0006068; P:ethanol catabolic process; IEA:UniProtKB-UniPathway. GO:0006629; P:lipid metabolic process; TAS:ProtInc. |
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Pfam | |
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PRINTS | |