Tag | Content |
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CPLM ID | CPLM-022680 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein piccolo |
Protein Synonyms/Alias | Aczonin; Brain-derived HLMN protein; Multidomain presynaptic cytomatrix protein |
Gene Name | Pclo |
Gene Synonyms/Alias | Acz |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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1062 | GQLGDMDKMPPASSG | ubiquitination | [1] | 1326 | SDEKDLLKGLKKDSF | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking. |
Sequence Annotation | DOMAIN 4424 4518 PDZ. DOMAIN 4637 4735 C2 1. DOMAIN 4952 5042 C2 2. ZN_FING 532 556 C4-type (Potential). ZN_FING 997 1020 C4-type (Potential). REGION 401 500 10 X 10 AA tandem approximate repeats of MOD_RES 625 625 Phosphoserine. MOD_RES 748 748 Phosphoserine. MOD_RES 860 860 Phosphothreonine. MOD_RES 1120 1120 Phosphothreonine. MOD_RES 1340 1340 Phosphoserine. MOD_RES 1341 1341 Phosphoserine. MOD_RES 1400 1400 Phosphoserine. MOD_RES 1439 1439 Phosphoserine. MOD_RES 1444 1444 Phosphoserine. MOD_RES 1457 1457 Phosphoserine. MOD_RES 1575 1575 Phosphoserine. MOD_RES 1585 1585 Phosphoserine. MOD_RES 1760 1760 Phosphothreonine. MOD_RES 1763 1763 Phosphoserine. MOD_RES 1766 1766 Phosphoserine. MOD_RES 1772 1772 Phosphoserine. MOD_RES 1808 1808 Phosphoserine. MOD_RES 1828 1828 Phosphotyrosine. MOD_RES 1829 1829 Phosphoserine. MOD_RES 2998 2998 Phosphothreonine. MOD_RES 3358 3358 Phosphoserine. MOD_RES 3376 3376 Phosphothreonine. MOD_RES 3513 3513 Phosphothreonine. MOD_RES 3545 3545 Phosphoserine. MOD_RES 3610 3610 Phosphoserine. MOD_RES 3616 3616 Phosphoserine. MOD_RES 3761 3761 Phosphotyrosine. MOD_RES 3763 3763 Phosphoserine. MOD_RES 3894 3894 Phosphothreonine. MOD_RES 3895 3895 Phosphothreonine. MOD_RES 3936 3936 Phosphoserine. MOD_RES 3952 3952 Phosphoserine. MOD_RES 4286 4286 Phosphoserine. MOD_RES 4290 4290 Phosphoserine. MOD_RES 4293 4293 Phosphoserine. MOD_RES 4325 4325 Phosphoserine. CARBOHYD 2686 2686 O-linked (GlcNAc). CARBOHYD 2960 2960 O-linked (GlcNAc). |
Keyword | Alternative splicing; Calcium; Calcium/phospholipid-binding; Cell junction; Complete proteome; Glycoprotein; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Synapse; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 5068 AA |
Protein Sequence | MGNEASLEGE GLPEGLAAAA GGAGGSGSAL HPGIPAGMEA DLSQLSEEER RQIAAVMSRA 60 QGLPKGSVPA AAAESPSMHR KQELDSSQAP QQPGKPPDPG RPPQHGLSKS RTTDTFRSEQ 120 KLPGRSPSTI SLKESKSRTD FKEEYKSSMM PGFFSDVNPL SAVSSVVNKF NPFDLISDSE 180 AVQEETTKKQ KVAQKDQGKS EGITKPSLQQ PSPKLIPKQQ GPGKEVIPQD IPSKSVSSQQ 240 AEKTKPQAPG TAKPSQQSPA QTPAQQAKPV AQQPGPAKAT VQQPGPAKSP AQPAGTGKSP 300 AQPPVTAKPP AQQAGLEKTS LQQPGPKSLA QTPGQGKVPP GPAKSPAQQP GTAKLPAQQP 360 GPQTAAKVPG PTKTPAQLSG PGKTPAQQPG PTKPSPQQPI PAKPQPQQPV ATKPQPQQPA 420 PAKPQPQHPT PAKPQPQHPT PAKPQPQQPT PAKPQPQQPT PAKPQPQQPT PAKPQPQHPT 480 PAKPQPQQPG LGKPSAQQPS KSISQTVTGR PLQAPPTSAA QAPAQGLSKT ICPLCNTTEL 540 LLHTPEKANF NTCTECQSTV CSLCGFNPNP HLTEIKEWLC LNCQMQRALG GELAAIPSSP 600 QPTPKAASVQ PATASKSPVP SQQASPKKEL PSKQDSPKAP ESKKPPPLVK QPTLHGPTPA 660 TAPQPPVAEA LPKPAPPKKP SAALPEQAKA PVADVEPKQP KTTETLTDSP SSAAATSKPA 720 ILSSQVQAQA QVTTAPPLKT DSAKTSQSFP PTGDTITPLD SKAMPRPASD SKIVSHPGPT 780 SESKDPVQKK EEPKKAQTKV TPKPDTKPVP KGSPTPSGTR PTTGQATPQS QQPPKPPEQS 840 RRFSLNLGGI ADAPKSQPTT PQETVTGKLF GFGASIFSQA SNLISTAGQQ APHPQTGPAA 900 PSKQAPPPSQ TLAAQGPPKS TGPHPSAPAK TTAVKKETKG PAAENLEAKP VQAPTVKKAE 960 KDKKPPPGKV SKPPPTEPEK AVLAQKPDKT TKPKPACPLC RTELNVGSQD PPNFNTCTEC 1020 KNQVCNLCGF NPTPHLTEIQ EWLCLNCQTQ RAISGQLGDM DKMPPASSGP KASPVPAPAE 1080 PPPQKTPTAA HAKGKKKETE VKAETEKQIP EKETPSIEKT PPAVATDQKL EESEVTKSLV 1140 SVLPEKKPSE EEKALPADKK EKKPPAAEAP PLEEKKPIPD DQKLPPDAKP SASEGEEKRD 1200 LLKAHVQIPE EGPIGKVASL ACEGEQQPDT RPEDLPGATP QTLPKDRQKE SRDVTQPQAE 1260 GTAKEGRGEP SKDRTEKEED KSDTSSSQQP KSPQGLSDTG YSSDGISGSL GEIPSLIPSD 1320 EKDLLKGLKK DSFSQESSPS SPSDLAKLES TVLSILEAQA STLVGEKAEK KTQPQKVSPE 1380 QPQDQQKTQT PSETRDISIS EEEIKESQEK KVTSKKDSAQ GFPSRKEHKE NPELVDDLSP 1440 RRASYDSVED SSESENSPVA RRKRRTSIGS SSSEEYKQED SQGSGEDEDF IRKQIIEMSA 1500 DEDASGSEDE EFIRSQLKEI GGVTESQKRE ETKGKGKSPA GKHRRLTRKS STSFDDDAGR 1560 RHSWHDEDDE TFDESPELKF RETKSQESEE LVVAGGGGLR RFKTIELNST VTDKYSAESS 1620 QKKTTLYFDE EPELEMESLT DSPEDRSRGE GSSSLHASSF TPGTSPTSVS SLDEDSDSSP 1680 SHKKGESKQQ RKARHRSHGP LLPTIEDSSE EEELREEEEL LKEQEKQREL EQQQRKSSSK 1740 KSKKDKDELR AQRRRERPKT PPSNLSPIED ASPTEELRQA AEMEELHRSS CSEYSPSIES 1800 DPEGFEISPE KIIEVQKVYK LPTAVSLYSP TDEQSVMQKE GAQKALKSAE EMYEEMMHKP 1860 HKYKAFPAAN ERDEVFEKEP LYGGMLIEDY IYESLVEDTY NGSVDGSLLT RQDEQNGFMQ 1920 QRGREQKIRL QEQIYDDPMQ KITDLQKEFY ELESLHSIVP QEDIVSSSYI IPESHEIVDL 1980 GSMVTSTSEE KKLLDADAAY EELMKRQQMQ VTDGSSLIQT TMGDDMAEST LDFDRVQDAS 2040 LTSSILSGAS LTDSTSSATL SIPDVKITQH FSTEEFEDEY VTDYTREIQE IIAHESLILT 2100 YSEPSESATS VPPSDTPSLT SSISSVCTTD SSSPVTTLDS LTTVYTEPAD VITKFKDSEE 2160 ISSTYFPGSV IDYPEDIGVS LDRTITPESR TNADQIMISF PGIAPSITES VATKPERPQA 2220 DTISTDLPIS EKELIKGKKE TGDGIILEVL DAYKDKREES EAELTKISLP ETGLAPTPSS 2280 QTKEQPGSPH SVSGEILGQE KPTYRSPSGG LPVSTHPSKS HPFFRSSSLD ISAQPPPPPP 2340 PPPPPPPPPP PPPPPPLPPA TSPKPPTYPK RKLAAAAPVA PTAIVTAHAD AIPTVEATAA 2400 RRSNGLPATK ICAAAPPPVP PKPSSIPTGL VFTHRPEASK PPIAPKPAVP EIPVTTQKTT 2460 DTCPKPTGLP LTSNMSLNLV TSADYKLPSP TSPLSPHSNK SSPRYSKSLM ETYVVITLPS 2520 EPGTPTDSSA AQAITSWPLG SPPKDLVSLE TVFSVVPPMT STEIPSASQP TLYTSGALGT 2580 FSVTPAVTAS LFQTVPTSLT QFLPAEASKP EVSAVSSAVP SVAPRSVSIP IPPEPLALDR 2640 HQYKENGKLP LIGDAIDLRT IPKSEVKVTE KCMDLSASAM DVKRQTTANE VYRRQISAVQ 2700 PSIINLSAAS SLGTPVTMDS KTVAVVTCTD TTIYTTGTES QVGIEHAVTS PLQLTTSKHT 2760 ELQYRKPSSQ AFPMIRDEAP INLSLGPSTQ AVTLAVTKPV TVPPVGVTNG WTDSTISQGI 2820 TDGEVVDLST SKSHRTVVTM DESTSNVVTK IIEDEEKPVD LTAGRRAVCC DMVYKLPFGR 2880 SCTAQQPATT LPEDRFGYRD DHYQYDRSGP YGYRGIGGMK PSMSDTNLAE AGHFFYKSKN 2940 AFDYSGGTEA AVDLTSGRVS TGEVMDYSSK TTGPYPETRQ VISGVGISTP QYSTARMTPP 3000 PGPQYGVGSV LRSSNGVVYS SVATPIPSTF AITTQPGSIF STTVRDLSGI HTTDAITSLS 3060 ALHQSQPMPR SYFITTGASE TDISVTSIDI NASLQTITME TLPAETMDSV PTLTTASEVF 3120 SEVVGEESTL LIVPDEDKQQ QQLDLERELL ELEKIKQQRF AEELEWERQE IQRFREQEKI 3180 MVQKKLEELQ SMKQHLLYQQ EEERQAQFMM RQETLAQQQL QLEQIQQLQQ QLHQQLEEQK 3240 LRQIYQYNYE PSGTASPQTT TEQAILEGQY VATEGSQFWA TEDATTTAST VVAIEIPQSQ 3300 GWYTVQSDGV TQYIAPPGIL STVSEIPLTD VVVKEEKQPK KRSSGAKVRG QYDEMGESMA 3360 DDPRNLKKIV DSGVQTDDEE TADRTYASRR RRTKKSVDTS VQTDDEDQDE WDMPSRSRRK 3420 ARTGKYGDST AEGDKTKPPS KVSSVAVQTV AEISVQTEPL GTIRTPSIRA RVDAKVEIIK 3480 HISAPEKTYK GGSLGCQTET DPDTQSPPYM GATSPPKDKK RPTPLEIGYS SSHLRADPTV 3540 QLAPSPPKSP KVLYSPISPL SPGHALEPAF VPYEKPLPDD ISPQKVLHPD MAKVPPASPK 3600 TAKMMQRSMS DPKPLSPTAD ESSRAPFQYS EGFTAKGSQT TSGTQKKVKR TLPNPPPEEA 3660 STGTQSTYST MGTASRRRMC RTNTMARAKI LQDIDRELDL VERESAKLRK KQAELDEEEK 3720 EIDAKLRYLE MGINRRKEAL LKEREKRERA YLQGVAEDRD YMSDSEVSST RPSRVESQHG 3780 IERPRTAPQT EFSQFIPPQT QTEAQLVPPT SPYTQYQYSS PALPTQAPTP YTQQSHFQQQ 3840 TLYHQQVSPY QTQPTFQAVA TMSFTPQAQP TPTPQPSYQL PSQMMVIQQK PRQTTLYLEP 3900 KITSTYEVIR NQPLMIAPVS TDNTYAVSHL GSKYNSLDLR IGLEERSSMA SSPISSISAD 3960 SFYADIDHHT SRNYVLIDDI GDITKGTAAL SSAFSLHEKD LSKTDRLLRT TETRRSQEVT 4020 DFLAPLQTSS RLHSYVKAEE DSMEDPYELK LLKHQIKQEF RRGTESLDHL AGLSHYYHAD 4080 TSYRHFPKSE KYSISRLTLE KQAAKQLPAA ILYQKQSKHK KALIDPKMSK FSPIQESRDL 4140 EPDYPTYLSS STSSIGGISS RARLLQDDIT FGLRKNITDQ QKFMGSSLGS GLGTLGNTIR 4200 SALQDEADKP YSSGSRSRPS SRPSSVYGLD LSIKRDSSSS SLRLKAQEAE ALDVSFGHSS 4260 SSARTKPTSL PISQSRGRIP IVAQNSEEES PLSPVGQPMG MARAAAGPLP PISADTRDQF 4320 GSSHSLPEVQ QHMREESRTR GYDRDIAFIM DDFQHAMSDS EAYHLRREET DWFDKPRESR 4380 LENGHGLDRK LPERLVHSRP LSQHQEQILQ MNGKTMHYIF PHARIKITRD SKDHTVSGNG 4440 LGIRIVGGKE IPGHSGEIGA YIAKILPGGS AEHSGKLIEG MQVLEWNGIP LTSKTYEEVQ 4500 SIINQQSGEA EICVRLDLNM LSDSENPQHL ELHEPPKVVD KAKSPGVDPK QLAAELQKVS 4560 LQQSPLVMSS VVEKGAHAHS GPTSAGSSSV PSPGQPGSPS VSKKKHGGSK PTDVSKTASH 4620 PITGEIQLQI NYDLGNLIIH ILQARNLVPR DNNGYSDPFV KVYLLPGRGQ VMVVQNASVE 4680 YKRRTKYVQK SLNPEWNQTV IYKSISMEQL MKKTLEVTVW DYDRFSSNDF LGEVLIDLSS 4740 TSHLDNTPRW YPLKEQTESI EHGKSHSSQN SQQSPKPSVI KSRSHGIFPD PSKDMQVPTI 4800 EKSHSSPGSS KSSSEGHLRS HGPSRSQSKT SVAQTHLEDA GAAIAAAEAA VQQLRIQPTK 4860 PTNHRPAETS VSTGSSGSSV GSGYSVDSEG SSCVAGEPNL LPIPRIGKMG QNGQDPVKQP 4920 GMGAADTEAK TQVMGEIKLA LKKEMKTDGE QLIVEILQCR NITYKFKSPD HLPDLYVKIY 4980 VINIATQKKV IKKKTRVCRH DREPSFNETF RFSLSPAGHS LQILLFSNGG KFMKKTLIGE 5040 ACIWLDKVDL RKRIVNWHKL LMSPTQTH 5068 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |