UniProt Accession

 BOD1_HUMAN; Q96IK1; B4DXH8; Q9BTW1 

Genbank Protein ID

 AY303777; AK301982; CH471062; BC003114; BC007436 

Genbank Nucleotide ID

 AAP76182.1; BAG63390.1; EAW61396.1; AAH03114.2; AAH07436.2 

Protein Name

 Biorientation of chromosomes in cell division protein 1 

Protein Synonyms/Alias

 Biorientation defective protein 1; Protein FAM44B 

Gene Name

 BOD1 

Gene Synonyms/Alias

 FAM44B 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
108	EWNPTMNKNQLRNGL	ubiquitination	[1]
140	ISQVVDPKLNHIFRP	ubiquitination	[2, 3]
162	EFLAAQKKAAVPAPP	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. 

Sequence Annotation

  

Keyword

 Alternative splicing; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Kinetochore; Mitosis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 185 AA 

Protein Sequence

Gene Ontology

 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW. 

Interpro

 IPR026955; Bod1_like. 

Pfam

  

SMART

  

PROSITE

  

PRINTS